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TargetDNA polymerase beta
LigandBDBM50184748
Substrate/Competitorn/a
Meas. Tech.ChEMBL_356788
IC50 8700±n/a nM
Citation Doncaster JREtchells LLKershaw NMNakamura RRyan HTakeuchi RSakaguchi KSardarian AWhitehead RC Synthetic analogues of the manzamenones and plakoridines which inhibit DNA polymerase. Bioorg Med Chem Lett 16:2877-81 (2006) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
DNA polymerase beta
Name:DNA polymerase beta
Synonyms:DNA polymerase beta (Pol β)
Type:Protein
Mol. Mass.:38188.76
Organism:Homo sapiens (Human)
Description:n/a
Residue:335
Sequence:
MSKRKAPQETLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAK
KLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVSGIGPSAARKFVDEGIK
TLEDLRKNEDKLNHHQRIGLKYFGDFEKRIPREEMLQMQDIVLNEVKKVDSEYIATVCGS
FRRGAESSGDMDVLLTHPSFTSESTKQPKLLHQVVEQLQKVHFITDTLSKGETKFMGVCQ
LPSKNDEKEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRP
LGVTGVAGEPLPVDSEKDIFDYIQWKYREPKDRSE
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  Blast E-value cutoff:
BDBM50184748
n/a
NameBDBM50184748
Synonyms:(2S,3S,4R)-methyl 2-ethyl-4-hydroxy-5-(2-oxononadecylidene)-1-phenethylpyrrolidine-3-carboxylate | CHEMBL437883
TypeSmall organic molecule
Emp. Form.C35H57NO4
Mol. Mass.555.8314
SMILESCCCCCCCCCCCCCCCCCC(=O)C=C1[C@H](O)[C@H]([C@H](CC)N1CCc1ccccc1)C(=O)OC |w:19.18|
Structure
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