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TargetDNA polymerase beta
LigandBDBM50184749
Substrate/Competitorn/a
Meas. Tech.ChEMBL_356788 (CHEMBL861141)
IC50 30000±n/a nM
Citation Doncaster, JREtchells, LLKershaw, NMNakamura, RRyan, HTakeuchi, RSakaguchi, KSardarian, AWhitehead, RC Synthetic analogues of the manzamenones and plakoridines which inhibit DNA polymerase. Bioorg Med Chem Lett16:2877-81 (2006) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
DNA polymerase beta
Name:DNA polymerase beta
Synonyms:DNA polymerase beta (Pol β) | DPOLB_HUMAN | POLB
Type:Protein
Mol. Mass.:38188.76
Organism:Homo sapiens (Human)
Description:n/a
Residue:335
Sequence:
MSKRKAPQETLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAK
KLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVSGIGPSAARKFVDEGIK
TLEDLRKNEDKLNHHQRIGLKYFGDFEKRIPREEMLQMQDIVLNEVKKVDSEYIATVCGS
FRRGAESSGDMDVLLTHPSFTSESTKQPKLLHQVVEQLQKVHFITDTLSKGETKFMGVCQ
LPSKNDEKEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRP
LGVTGVAGEPLPVDSEKDIFDYIQWKYREPKDRSE
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50184749
n/a
NameBDBM50184749
Synonyms:(2S,3S,4R)-methyl 1-benzyl-2-ethyl-4-hydroxy-5-(2-oxotetradecylidene)pyrrolidine-3-carboxylate | CHEMBL379409
TypeSmall organic molecule
Emp. Form.C29H45NO4
Mol. Mass.471.6719
SMILESCCCCCCCCCCCCC(=O)C=C1[C@H](O)[C@H]([C@H](CC)N1Cc1ccccc1)C(=O)OC |w:14.13|
Structure
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