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TargetDNA polymerase beta
LigandBDBM50184753
Substrate/Competitorn/a
Meas. Tech.ChEMBL_356788
IC50>12500±n/a nM
Citation Doncaster JREtchells LLKershaw NMNakamura RRyan HTakeuchi RSakaguchi KSardarian AWhitehead RC Synthetic analogues of the manzamenones and plakoridines which inhibit DNA polymerase. Bioorg Med Chem Lett 16:2877-81 (2006) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
DNA polymerase beta
Name:DNA polymerase beta
Synonyms:DNA polymerase beta (Pol β)
Type:Protein
Mol. Mass.:38188.76
Organism:Homo sapiens (Human)
Description:n/a
Residue:335
Sequence:
MSKRKAPQETLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAK
KLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVSGIGPSAARKFVDEGIK
TLEDLRKNEDKLNHHQRIGLKYFGDFEKRIPREEMLQMQDIVLNEVKKVDSEYIATVCGS
FRRGAESSGDMDVLLTHPSFTSESTKQPKLLHQVVEQLQKVHFITDTLSKGETKFMGVCQ
LPSKNDEKEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRP
LGVTGVAGEPLPVDSEKDIFDYIQWKYREPKDRSE
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  Blast E-value cutoff:
BDBM50184753
n/a
NameBDBM50184753
Synonyms:(1R,1bR,2R,5S,5aS)-1a,3-dihexadecyl-6-oxo-1a,1b,2,5,5a,6-hexahydro-1H-cyclopropa[a]indene-2,5,6a-tricarboxylic acid trimethyl ester | CHEMBL207165
TypeSmall organic molecule
Emp. Form.C48H82O7
Mol. Mass.771.1605
SMILESCCCCCCCCCCCCCCCCC1=C[C@@H]([C@@H]2[C@H]([C@H]1C(=O)OC)[C@@]1(CCCCCCCCCCCCCCCC)C[C@@]1(C(=O)OC)C2=O)C(=O)OC |t:16|
Structure
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