Reaction Details |
| Report a problem with these data |
Target | DNA polymerase beta |
---|
Ligand | BDBM50184759 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_356788 (CHEMBL861141) |
---|
IC50 | 10000±n/a nM |
---|
Citation | Doncaster, JR; Etchells, LL; Kershaw, NM; Nakamura, R; Ryan, H; Takeuchi, R; Sakaguchi, K; Sardarian, A; Whitehead, RC Synthetic analogues of the manzamenones and plakoridines which inhibit DNA polymerase. Bioorg Med Chem Lett16:2877-81 (2006) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
DNA polymerase beta |
---|
Name: | DNA polymerase beta |
Synonyms: | DNA polymerase beta (Pol β) | DPOLB_HUMAN | POLB |
Type: | Protein |
Mol. Mass.: | 38188.76 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 335 |
Sequence: | MSKRKAPQETLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAK
KLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVSGIGPSAARKFVDEGIK
TLEDLRKNEDKLNHHQRIGLKYFGDFEKRIPREEMLQMQDIVLNEVKKVDSEYIATVCGS
FRRGAESSGDMDVLLTHPSFTSESTKQPKLLHQVVEQLQKVHFITDTLSKGETKFMGVCQ
LPSKNDEKEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRP
LGVTGVAGEPLPVDSEKDIFDYIQWKYREPKDRSE
|
|
|
BDBM50184759 |
---|
n/a |
---|
Name | BDBM50184759 |
Synonyms: | (2R,3S,4R)-methyl 1-(2-(1H-indol-3-yl)ethyl)-4-hydroxy-5-(2-oxotetradecylidene)-2-phenylpyrrolidine-3-carboxylate | CHEMBL437310 |
Type | Small organic molecule |
Emp. Form. | C36H48N2O4 |
Mol. Mass. | 572.7773 |
SMILES | CCCCCCCCCCCCC(=O)C=C1[C@H](O)[C@H]([C@@H](N1CCc1c[nH]c2ccccc12)c1ccccc1)C(=O)OC |w:14.13| |
Structure |
|