| Reaction Details |
|---|
 | Report a problem with these data |
| Target | DNA polymerase alpha catalytic subunit |
|---|
| Ligand | BDBM50184748 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_356787 (CHEMBL861140) |
|---|
| IC50 | 8900±n/a nM |
|---|
| Citation |  Doncaster, JR; Etchells, LL; Kershaw, NM; Nakamura, R; Ryan, H; Takeuchi, R; Sakaguchi, K; Sardarian, A; Whitehead, RC Synthetic analogues of the manzamenones and plakoridines which inhibit DNA polymerase. Bioorg Med Chem Lett16:2877-81 (2006) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| DNA polymerase alpha catalytic subunit |
|---|
| Name: | DNA polymerase alpha catalytic subunit |
|---|
| Synonyms: | DNA polymerase (alpha/delta/epsilon) | DNA polymerase alpha subunit | DPOLA_HUMAN | POLA | POLA1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 165895.25 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1365493 |
|---|
| Residue: | 1462 |
|---|
| Sequence: | MAPVHGDDSLSDSGSFVSSRARREKKSKKGRQEALERLKKAKAGEKYKYEVEDFTGVYEE
VDEEQYSKLVQARQDDDWIVDDDGIGYVEDGREIFDDDLEDDALDADEKGKDGKARNKDK
RNVKKLAVTKPNNIKSMFIACAGKKTADKAVDLSKDGLLGDILQDLNTETPQITPPPVMI
LKKKRSIGASPNPFSVHTATAVPSGKIASPVSRKEPPLTPVPLKRAEFAGDDVQVESTEE
EQESGAMEFEDGDFDEPMEVEEVDLEPMAAKAWDKESEPAEEVKQEADSGKGTVSYLGSF
LPDVSCWDIDQEGDSSFSVQEVQVDSSHLPLVKGADEEQVFHFYWLDAYEDQYNQPGVVF
LFGKVWIESAETHVSCCVMVKNIERTLYFLPREMKIDLNTGKETGTPISMKDVYEEFDEK
IATKYKIMKFKSKPVEKNYAFEIPDVPEKSEYLEVKYSAEMPQLPQDLKGETFSHVFGTN
TSSLELFLMNRKIKGPCWLEVKSPQLLNQPVSWCKVEAMALKPDLVNVIKDVSPPPLVVM
AFSMKTMQNAKNHQNEIIAMAALVHHSFALDKAAPKPPFQSHFCVVSKPKDCIFPYAFKE
VIEKKNVKVEVAATERTLLGFFLAKVHKIDPDIIVGHNIYGFELEVLLQRINVCKAPHWS
KIGRLKRSNMPKLGGRSGFGERNATCGRMICDVEISAKELIRCKSYHLSELVQQILKTER
VVIPMENIQNMYSESSQLLYLLEHTWKDAKFILQIMCELNVLPLALQITNIAGNIMSRTL
MGGRSERNEFLLLHAFYENNYIVPDKQIFRKPQQKLGDEDEEIDGDTNKYKKGRKKAAYA
GGLVLDPKVGFYDKFILLLDFNSLYPSIIQEFNICFTTVQRVASEAQKVTEDGEQEQIPE
LPDPSLEMGILPREIRKLVERRKQVKQLMKQQDLNPDLILQYDIRQKALKLTANSMYGCL
GFSYSRFYAKPLAALVTYKGREILMHTKEMVQKMNLEVIYGDTDSIMINTNSTNLEEVFK
LGNKVKSEVNKLYKLLEIDIDGVFKSLLLLKKKKYAALVVEPTSDGNYVTKQELKGLDIV
RRDWCDLAKDTGNFVIGQILSDQSRDTIVENIQKRLIEIGENVLNGSVPVSQFEINKALT
KDPQDYPDKKSLPHVHVALWINSQGGRKVKAGDTVSYVICQDGSNLTASQRAYAPEQLQK
QDNLTIDTQYYLAQQIHPVVARICEPIDGIDAVLIATWLGLDPTQFRVHHYHKDEENDAL
LGGPAQLTDEEKYRDCERFKCPCPTCGTENIYDNVFDGSGTDMEPSLYRCSNIDCKASPL
TFTVQLSNKLIMDIRRFIKKYYDGWLICEEPTCRNRTRHLPLQFSRTGPLCPACMKATLQ
PEYSDKSLYTQLCFYRYIFDAECALEKLTTDHEKDKLKKQFFTPKVLQDYRKLKNTAEQF
LSRSGYSEVNLSKLFAGCAVKS
|
|
|
|---|
| BDBM50184748 |
|---|
| n/a |
|---|
| Name | BDBM50184748 |
|---|
| Synonyms: | (2S,3S,4R)-methyl 2-ethyl-4-hydroxy-5-(2-oxononadecylidene)-1-phenethylpyrrolidine-3-carboxylate | CHEMBL437883 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C35H57NO4 |
|---|
| Mol. Mass. | 555.8314 |
|---|
| SMILES | CCCCCCCCCCCCCCCCCC(=O)C=C1[C@H](O)[C@H]([C@H](CC)N1CCc1ccccc1)C(=O)OC |w:19.18| |
|---|
| Structure | 
|
|---|
Search and Browse
