| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Vascular endothelial growth factor receptor 2 |
|---|
| Ligand | BDBM50185183 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_374541 (CHEMBL862848) |
|---|
| IC50 | 31±n/a nM |
|---|
| Citation |  McBride, CM; Renhowe, PA; Heise, C; Jansen, JM; Lapointe, G; Ma, S; Piñeda, R; Vora, J; Wiesmann, M; Shafer, CM Design and structure-activity relationship of 3-benzimidazol-2-yl-1H-indazoles as inhibitors of receptor tyrosine kinases. Bioorg Med Chem Lett16:3595-9 (2006) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Vascular endothelial growth factor receptor 2 |
|---|
| Name: | Vascular endothelial growth factor receptor 2 |
|---|
| Synonyms: | Flk-1 | Flk1 | Kdr | VEGFR-2 (KDR) | VGFR2_MOUSE | Vascular endothelial growth factor receptor 2 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 152506.58 |
|---|
| Organism: | Mus musculus |
|---|
| Description: | ChEMBL_1469997 |
|---|
| Residue: | 1367 |
|---|
| Sequence: | MESKALLAVALWFCVETRAASVGLPGDFLHPPKLSTQKDILTILANTTLQITCRGQRDLD
WLWPNAQRDSEERVLVTECGGGDSIFCKTLTIPRVVGNDTGAYKCSYRDVDIASTVYVYV
RDYRSPFIASVSDQHGIVYITENKNKTVVIPCRGSISNLNVSLCARYPEKRFVPDGNRIS
WDSEIGFTLPSYMISYAGMVFCEAKINDETYQSIMYIVVVVGYRIYDVILSPPHEIELSA
GEKLVLNCTARTELNVGLDFTWHSPPSKSHHKKIVNRDVKPFPGTVAKMFLSTLTIESVT
KSDQGEYTCVASSGRMIKRNRTFVRVHTKPFIAFGSGMKSLVEATVGSQVRIPVKYLSYP
APDIKWYRNGRPIESNYTMIVGDELTIMEVTERDAGNYTVILTNPISMEKQSHMVSLVVN
VPPQIGEKALISPMDSYQYGTMQTLTCTVYANPPLHHIQWYWQLEEACSYRPGQTSPYAC
KEWRHVEDFQGGNKIEVTKNQYALIEGKNKTVSTLVIQAANVSALYKCEAINKAGRGERV
ISFHVIRGPEITVQPAAQPTEQESVSLLCTADRNTFENLTWYKLGSQATSVHMGESLTPV
CKNLDALWKLNGTMFSNSTNDILIVAFQNASLQDQGDYVCSAQDKKTKKRHCLVKQLIIL
ERMAPMITGNLENQTTTIGETIEVTCPASGNPTPHITWFKDNETLVEDSGIVLRDGNRNL
TIRRVRKEDGGLYTCQACNVLGCARAETLFIIEGAQEKTNLEVIILVGTAVIAMFFWLLL
VILVRTVKRANEGELKTGYLSIVMDPDELPLDERCERLPYDASKWEFPRDRLKLGKPLGR
GAFGQVIEADAFGIDKTATCKTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLL
GACTKPGGPLMVIVEFSKFGNLSTYLRGKRNEFVPYKSKGARFRQGKDYVGELSVDLKRR
LDSITSSQSSASSGFVEEKSLSDVEEEEASEELYKDFLTLEHLICYSFQVAKGMEFLASR
KCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVY
TIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDC
WHEDPNQRPSFSELVEHLGNLLQANAQQDGKDYIVLPMSETLSMEEDSGLSLPTSPVSCM
EEEEVCDPKFHYDNTAGISHYLQNSKRKSRPVSVKTFEDIPLEEPEVKVIPDDSQTDSGM
VLASEELKTLEDRNKLSPSFGGMMPSKSRESVASEGSNQTSGYQSGYHSDDTDTTVYSSD
EAGLLKMVDAAVHADSGTTLQLTSCLNGSGPVPAPPPTPGNHERGAA
|
|
|
|---|
| BDBM50185183 |
|---|
| n/a |
|---|
| Name | BDBM50185183 |
|---|
| Synonyms: | CHEMBL380372 | methyl 3-(5-(4-(piperidin-1-yl)piperidin-1-yl)-1H-benzo[d]imidazol-2-yl)-1H-indazole-5-carboxylate |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H30N6O2 |
|---|
| Mol. Mass. | 458.5554 |
|---|
| SMILES | COC(=O)c1ccc2[nH]nc(-c3nc4ccc(cc4[nH]3)N3CCC(CC3)N3CCCCC3)c2c1 |
|---|
| Structure | 
|
|---|
Search and Browse
