Ki Summary

Reaction Details

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Target

Neuropeptide Y receptor type 4

Ligand

BDBM50049744

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_344937 (CHEMBL870716)

30±n/a nM

Citation

Balasubramaniam, A; Mullins, DE; Lin, S; Zhai, W; Tao, Z; Dhawan, VC; Guzzi, M; Knittel, JJ; Slack, K; Herzog, H; Parker, EM Neuropeptide Y (NPY) Y4 receptor selective agonists based on NPY(32-36): development of an anorectic Y4 receptor selective agonist with picomolar affinity. J Med Chem49:2661-5 (2006) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Neuropeptide Y receptor type 4

Name:

Neuropeptide Y receptor type 4

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

42207.58

Organism:

Homo sapiens (Human)

Description:

NPY-Y4 PPYR1 HUMAN::P50391

Residue:

375

Sequence:

MNTSHLLALLLPKSPQGENRSKPLGTPYNFSEHCQDSVDVMVFIVTSYSIETVVGVLGNL
CLMCVTVRQKEKANVTNLLIANLAFSDFLMCLLCQPLTAVYTIMDYWIFGETLCKMSAFI
QCMSVTVSILSLVLVALERHQLIINPTGWKPSISQAYLGIVLIWVIACVLSLPFLANSIL
ENVFHKNHSKALEFLADKVVCTESWPLAHHRTIYTTFLLLFQYCLPLGFILVCYARIYRR
LQRQGRVFHKGTYSLRAGHMKQVNVVLVVMVVAFAVLWLPLHVFNSLEDWHHEAIPICHG
NLIFLVCHLLAMASTCVNPFIYGFLNTNFKKEIKALVLTCQQSAPLEESEHLPLSTVHTE
VSKGSLRLSGRSNPI

BDBM50049744

n/a

Name

BDBM50049744

Synonyms:

CHEMBL438548 | NPY-analogs | [Cys-Trp-Arg-Nva-Arg-Tyr-NH2]2

Type

Small organic molecule

Emp. Form.

C80H118N28O14S2

Mol. Mass.

1760.102

SMILES

CCC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CSSC[C@H](N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O

Structure