| Reaction Details |
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 | Report a problem with these data |
| Target | Sphingosine 1-phosphate receptor 3 |
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| Ligand | BDBM50185529 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_374028 (CHEMBL864690) |
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| IC50 | >1000±n/a nM |
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| Citation |  Yan, L; Budhu, R; Huo, P; Lynch, CL; Hale, JJ; Mills, SG; Hajdu, R; Keohane, CA; Rosenbach, MJ; Milligan, JA; Shei, GJ; Chrebet, G; Bergstrom, J; Card, D; Mandala, SM 2-Aryl(pyrrolidin-4-yl)acetic acids are potent agonists of sphingosine-1-phosphate (S1P) receptors. Bioorg Med Chem Lett16:3564-8 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sphingosine 1-phosphate receptor 3 |
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| Name: | Sphingosine 1-phosphate receptor 3 |
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| Synonyms: | C9orf108 | C9orf47 | EDG3 | Endothelial differentiation G-protein coupled receptor 3 | S1P receptor 3 | S1P receptor Edg-3 | S1P3 | S1PR3 | S1PR3_HUMAN | Sphingosine 1-phosphate receptor | Sphingosine 1-phosphate receptor 3 (S1P3) | Sphingosine 1-phosphate receptor Edg-3 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 42278.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q99500 |
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| Residue: | 378 |
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| Sequence: | MATALPPRLQPVRGNETLREHYQYVGKLAGRLKEASEGSTLTTVLFLVICSFIVLENLMV
LIAIWKNNKFHNRMYFFIGNLALCDLLAGIAYKVNILMSGKKTFSLSPTVWFLREGSMFV
ALGASTCSLLAIAIERHLTMIKMRPYDANKRHRVFLLIGMCWLIAFTLGALPILGWNCLH
NLPDCSTILPLYSKKYIAFCISIFTAILVTIVILYARIYFLVKSSSRKVANHNNSERSMA
LLRTVVIVVSVFIACWSPLFILFLIDVACRVQACPILFKAQWFIVLAVLNSAMNPVIYTL
ASKEMRRAFFRLVCNCLVRGRGARASPIQPALDPSRSKSSSSNNSSHSPKVKEDLPHTAP
SSCIMDKNAALQNGIFCN
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| BDBM50185529 |
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| n/a |
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| Name | BDBM50185529 |
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| Synonyms: | 2-(trans-5-(4-(5-(4-cyclopentylphenyl)-1,2,4-oxadiazol-3-yl)phenyl)pyrrolidin-3-yl)acetic acid | CHEMBL211006 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H27N3O3 |
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| Mol. Mass. | 417.5002 |
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| SMILES | OC(=O)C[C@@H]1CN[C@H](C1)c1ccc(cc1)-c1noc(n1)-c1ccc(cc1)C1CCCC1 |
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| Structure | 
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