Ki Summary

Reaction Details

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Target

Sphingosine 1-phosphate receptor 2

Ligand

BDBM50158335

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_374027 (CHEMBL864689)

IC50

>10000±n/a nM

Citation

Yan, L; Budhu, R; Huo, P; Lynch, CL; Hale, JJ; Mills, SG; Hajdu, R; Keohane, CA; Rosenbach, MJ; Milligan, JA; Shei, GJ; Chrebet, G; Bergstrom, J; Card, D; Mandala, SM 2-Aryl(pyrrolidin-4-yl)acetic acids are potent agonists of sphingosine-1-phosphate (S1P) receptors. Bioorg Med Chem Lett16:3564-8 (2006) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Sphingosine 1-phosphate receptor 2

Name:

Sphingosine 1-phosphate receptor 2

Synonyms:

Type:

G Protein-Coupled Receptor (GPCR)

Mol. Mass.:

38883.16

Organism:

Homo sapiens (Human)

Description:

Membranes isolated from S1P2-transfected CHO cells were used in ligand binding assay.

Residue:

353

Sequence:

MGSLYSEYLNPNKVQEHYNYTKETLETQETTSRQVASAFIVILCCAIVVENLLVLIAVAR
NSKFHSAMYLFLGNLAASDLLAGVAFVANTLLSGSVTLRLTPVQWFAREGSAFITLSASV
FSLLAIAIERHVAIAKVKLYGSDKSCRMLLLIGASWLISLVLGGLPILGWNCLGHLEACS
TVLPLYAKHYVLCVVTIFSIILLAIVALYVRIYCVVRSSHADMAAPQTLALLKTVTIVLG
VFIVCWLPAFSILLLDYACPVHSCPILYKAHYFFAVSTLNSLLNPVIYTWRSRDLRREVL
RPLQCWRPGVGVQGRRRGGTPGHHLLPLRSSSSLERGMHMPTSPTFLEGNTVV

BDBM50158335

n/a

Name

BDBM50158335

Synonyms:

1-(4-((4-phenyl-5-(trifluoromethyl)thiophen-2-yl)methoxy)benzyl)azetidine-3-carboxylic acid | 1-[4-(4-Phenyl-5-trifluoromethyl-thiophen-2-ylmethoxy)-benzyl]-azetidine-3-carboxylic acid | CHEMBL425563

Type

Small organic molecule

Emp. Form.

C23H20F3NO3S

Mol. Mass.

447.47

SMILES

OC(=O)C1CN(Cc2ccc(OCc3cc(c(s3)C(F)(F)F)-c3ccccc3)cc2)C1

Structure