Reaction Details |
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Target | Delta-type opioid receptor |
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Ligand | BDBM50185788 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_372755 (CHEMBL871099) |
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Ki | >5000±n/a nM |
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Citation | Bignan, GC; Battista, K; Connolly, PJ; Orsini, MJ; Liu, J; Middleton, SA; Reitz, AB 3-(4-Piperidinyl)indoles and 3-(4-piperidinyl)pyrrolo-[2,3-b]pyridines as ligands for the ORL-1 receptor. Bioorg Med Chem Lett16:3524-8 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Delta-type opioid receptor |
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Name: | Delta-type opioid receptor |
Synonyms: | D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 40382.98 |
Organism: | Homo sapiens (Human) |
Description: | Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor. |
Residue: | 372 |
Sequence: | MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVC
AVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELL
CKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVG
VPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRL
RSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAAL
HLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTAC
TPSDGPGGGAAA
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BDBM50185788 |
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n/a |
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Name | BDBM50185788 |
Synonyms: | (2R)-1-(3-(1-(1,2-dihydroacenaphthylen-1-yl)piperidin-4-yl)-6-fluoro-1H-indol-1-yl)-3-(dimethylamino)propan-2-ol | CHEMBL379971 |
Type | Small organic molecule |
Emp. Form. | C30H34FN3O |
Mol. Mass. | 471.6089 |
SMILES | CN(C)C[C@@H](O)Cn1cc(C2CCN(CC2)C2Cc3cccc4cccc2c34)c2ccc(F)cc12 |
Structure |
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