| Reaction Details |
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 | Report a problem with these data |
| Target | C-C chemokine receptor type 8 |
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| Ligand | BDBM50185902 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_351818 (CHEMBL867801) |
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| Ki | 60±n/a nM |
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| Citation |  Ghosh, S; Elder, A; Guo, J; Mani, U; Patane, M; Carson, K; Ye, Q; Bennett, R; Chi, S; Jenkins, T; Guan, B; Kolbeck, R; Smith, S; Zhang, C; LaRosa, G; Jaffee, B; Yang, H; Eddy, P; Lu, C; Uttamsingh, V; Horlick, R; Harriman, G; Flynn, D Design, synthesis, and progress toward optimization of potent small molecule antagonists of CC chemokine receptor 8 (CCR8). J Med Chem49:2669-72 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-C chemokine receptor type 8 |
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| Name: | C-C chemokine receptor type 8 |
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| Synonyms: | CCR8 | CCR8_HUMAN | CKRL1 | CMKBR8 | CMKBRL2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 40855.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_454278 |
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| Residue: | 355 |
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| Sequence: | MDYTLDLSVTTVTDYYYPDIFSSPCDAELIQTNGKLLLAVFYCLLFVFSLLGNSLVILVL
VVCKKLRSITDVYLLNLALSDLLFVFSFPFQTYYLLDQWVFGTVMCKVVSGFYYIGFYSS
MFFITLMSVDRYLAVVHAVYALKVRTIRMGTTLCLAVWLTAIMATIPLLVFYQVASEDGV
LQCYSFYNQQTLKWKIFTNFKMNILGLLIPFTIFMFCYIKILHQLKRCQNHNKTKAIRLV
LIVVIASLLFWVPFNVVLFLTSLHSMHILDGCSISQQLTYATHVTEIISFTHCCVNPVIY
AFVGEKFKKHLSEIFQKSCSQIFNYLGRQMPRESCEKSSSCQQHSSRSSSVDYIL
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| BDBM50185902 |
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| n/a |
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| Name | BDBM50185902 |
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| Synonyms: | 1-[3-(2-methoxy-phenoxy)-benzyl]-4-[(4-phenyl-piperidine-4-carbonyl)-amino]-piperidine-4-carboxylic acid | CHEMBL379834 |
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| Type | Small organic molecule |
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| Emp. Form. | C32H37N3O5 |
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| Mol. Mass. | 543.6533 |
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| SMILES | COc1ccccc1Oc1cccc(CN2CCC(CC2)(NC(=O)C2(CCNCC2)c2ccccc2)C(O)=O)c1 |
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| Structure | 
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