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TargetC-C chemokine receptor type 5
LigandBDBM50185965
Substrate/Competitorn/a
Meas. Tech.ChEMBL_351943 (CHEMBL870789)
IC50 26±n/a nM
Citation Imamura, SIchikawa, TNishikawa, YKanzaki, NTakashima, KNiwa, SIizawa, YBaba, MSugihara, Y Discovery of a piperidine-4-carboxamide CCR5 antagonist (TAK-220) with highly potent Anti-HIV-1 activity. J Med Chem49:2784-93 (2006) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
C-C chemokine receptor type 5
Name:C-C chemokine receptor type 5
Synonyms:C-C CKR-5 | C-C chemokine receptor type 5 | CC-CKR-5 | CCR-5 | CCR5 | CCR5/mu opioid receptor complex | CCR5_HUMAN | CD_antigen=CD195 | CHEMR13 | CMKBR5 | HIV-1 fusion coreceptor
Type:Enzyme
Mol. Mass.:40540.21
Organism:Homo sapiens (Human)
Description:P51681
Residue:352
Sequence:
MDYQVSSPIYDINYYTSEPCQKINVKQIAARLLPPLYSLVFIFGFVGNMLVILILINCKR
LKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQWDFGNTMCQLLTGLYFIGFFSGIFFII
LLTIDRYLAVVHAVFALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQKEGLHYTCSS
HFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTLLRCRNEKKRHRAVRLIFTI
MIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQVTETLGMTHCCINPIIYAFV
GEKFRNYLLVFFQKHIAKRFCKCCSIFQQEAPERASSVYTRSTGEQEISVGL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50185965
n/a
NameBDBM50185965
Synonyms:1-acetyl-N-(3,4-dichlorophenyl)-N-{3-[4-(4-fluoroanilino)piperidin-1-yl]propyl}piperidine-4-carboxamide | CHEMBL205851
TypeSmall organic molecule
Emp. Form.C28H35Cl2FN4O2
Mol. Mass.549.508
SMILESCC(=O)N1CCC(CC1)C(=O)N(CCCN1CCC(CC1)Nc1ccc(F)cc1)c1ccc(Cl)c(Cl)c1
Structure
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