Reaction Details |
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Target | Malonyl-CoA decarboxylase, mitochondrial |
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Ligand | BDBM50186052 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_371874 (CHEMBL871585) |
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IC50 | 20±n/a nM |
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Citation | Cheng, JF; Mak, CC; Huang, Y; Penuliar, R; Nishimoto, M; Zhang, L; Chen, M; Wallace, D; Arrhenius, T; Chu, D; Yang, G; Barbosa, M; Barr, R; Dyck, JR; Lopaschuk, GD; Nadzan, AM Heteroaryl substituted bis-trifluoromethyl carbinols as malonyl-CoA decarboxylase inhibitors. Bioorg Med Chem Lett16:3484-8 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Malonyl-CoA decarboxylase, mitochondrial |
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Name: | Malonyl-CoA decarboxylase, mitochondrial |
Synonyms: | DCMC_HUMAN | MLYCD | Malonyl-CoA decarboxylase |
Type: | PROTEIN |
Mol. Mass.: | 55018.37 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_665404 |
Residue: | 493 |
Sequence: | MRGFGPGLTARRLLPLRLPPRPPGPRLASGQAAGALERAMDELLRRAVPPTPAYELREKT
PAPAEGQCADFVSFYGGLAETAQRAELLGRLARGFGVDHGQVAEQSAGVLHLRQQQREAA
VLLQAEDRLRYALVPRYRGLFHHISKLDGGVRFLVQLRADLLEAQALKLVEGPDVREMNG
VLKGMLSEWFSSGFLNLERVTWHSPCEVLQKISEAEAVHPVKNWMDMKRRVGPYRRCYFF
SHCSTPGEPLVVLHVALTGDISSNIQAIVKEHPPSETEEKNKITAAIFYSISLTQQGLQG
VELGTFLIKRVVKELQREFPHLGVFSSLSPIPGFTKWLLGLLNSQTKEHGRNELFTDSEC
KEISEITGGPINETLKLLLSSSEWVQSEKLVRALQTPLMRLCAWYLYGEKHRGYALNPVA
NFHLQNGAVLWRINWMADVSLRGITGSCGLMANYRYFLEETGPNSTSYLGSKIIKASEQV
LSLVAQFQKNSKL
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BDBM50186052 |
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n/a |
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Name | BDBM50186052 |
Synonyms: | CHEMBL210190 | N-(4-cyanobenzyl)-N-(5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)thiazol-2-yl)isobutyramide |
Type | Small organic molecule |
Emp. Form. | C18H15F6N3O2S |
Mol. Mass. | 451.386 |
SMILES | CC(C)C(=O)N(Cc1ccc(cc1)C#N)c1ncc(s1)C(O)(C(F)(F)F)C(F)(F)F |
Structure |
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