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TargetRNA-directed RNA polymerase
LigandBDBM50186156
Substrate/Competitorn/a
Meas. Tech.ChEMBL_369598 (CHEMBL865371)
IC50 0.400000±n/a nM
Citation Chris Krueger, AMadigan, DLJiang, WWKati, WMLiu, DLiu, YMaring, CJMasse, SMcDaniel, KFMiddleton, TMo, HMolla, AMontgomery, DPratt, JKRockway, TWZhang, RKempf, DJ Inhibitors of HCV NS5B polymerase: synthesis and structure-activity relationships of N-alkyl-4-hydroxyquinolon-3-yl-benzothiadiazine sulfamides. Bioorg Med Chem Lett16:3367-70 (2006) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
RNA-directed RNA polymerase
Name:RNA-directed RNA polymerase
Synonyms:Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein
Type:Protein
Mol. Mass.:25173.95
Organism:Hepatitis C virus
Description:Q8JXU8
Residue:229
Sequence:
RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLT
CYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPP
QPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIM
FAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50186156
n/a
NameBDBM50186156
Synonyms:CHEMBL379613 | N-{3-[1-(cyclobutylamino)-4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl]-1,1-dioxo-2H-1,2,4-benzothiadiazin-7-yl}aminosulfonamide
TypeSmall organic molecule
Emp. Form.C20H20N6O6S2
Mol. Mass.504.539
SMILESNS(=O)(=O)Nc1ccc2N=C(NS(=O)(=O)c2c1)c1c(O)c2ccccc2n(NC2CCC2)c1=O |c:9|
Structure
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