Reaction Details |
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Target | RNA-directed RNA polymerase |
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Ligand | BDBM50186156 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_369598 (CHEMBL865371) |
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IC50 | 0.400000±n/a nM |
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Citation | Chris Krueger, A; Madigan, DL; Jiang, WW; Kati, WM; Liu, D; Liu, Y; Maring, CJ; Masse, S; McDaniel, KF; Middleton, T; Mo, H; Molla, A; Montgomery, D; Pratt, JK; Rockway, TW; Zhang, R; Kempf, DJ Inhibitors of HCV NS5B polymerase: synthesis and structure-activity relationships of N-alkyl-4-hydroxyquinolon-3-yl-benzothiadiazine sulfamides. Bioorg Med Chem Lett16:3367-70 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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RNA-directed RNA polymerase |
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Name: | RNA-directed RNA polymerase |
Synonyms: | Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein |
Type: | Protein |
Mol. Mass.: | 25173.95 |
Organism: | Hepatitis C virus |
Description: | Q8JXU8 |
Residue: | 229 |
Sequence: | RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLT
CYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPP
QPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIM
FAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
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BDBM50186156 |
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n/a |
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Name | BDBM50186156 |
Synonyms: | CHEMBL379613 | N-{3-[1-(cyclobutylamino)-4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl]-1,1-dioxo-2H-1,2,4-benzothiadiazin-7-yl}aminosulfonamide |
Type | Small organic molecule |
Emp. Form. | C20H20N6O6S2 |
Mol. Mass. | 504.539 |
SMILES | NS(=O)(=O)Nc1ccc2N=C(NS(=O)(=O)c2c1)c1c(O)c2ccccc2n(NC2CCC2)c1=O |c:9| |
Structure |
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