Reaction Details |
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Target | RNA-directed RNA polymerase |
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Ligand | BDBM50186185 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_366543 (CHEMBL871397) |
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IC50 | 7±n/a nM |
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Citation | Rockway, TW; Zhang, R; Liu, D; Betebenner, DA; McDaniel, KF; Pratt, JK; Beno, D; Montgomery, D; Jiang, WW; Masse, S; Kati, WM; Middleton, T; Molla, A; Maring, CJ; Kempf, DJ Inhibitors of HCV NS5B polymerase: synthesis and structure-activity relationships of N-1-benzyl and N-1-[3-methylbutyl]-4-hydroxy-1,8-naphthyridon-3-yl benzothiadiazine analogs containing substituents on the aromatic ring. Bioorg Med Chem Lett16:3833-8 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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RNA-directed RNA polymerase |
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Name: | RNA-directed RNA polymerase |
Synonyms: | Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein |
Type: | Protein |
Mol. Mass.: | 25173.95 |
Organism: | Hepatitis C virus |
Description: | Q8JXU8 |
Residue: | 229 |
Sequence: | RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLT
CYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPP
QPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIM
FAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
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BDBM50186185 |
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n/a |
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Name | BDBM50186185 |
Synonyms: | CHEMBL211408 | N-{3-[4-hydroxy-1-(3-methyl-butyl)-2-oxo-1,2-dihydro-[1,8]naphthyridin-3-yl]-1,1-dioxo-1,4-dihydro-1lambda*6*-benzo[1,2,4]thiadiazin-7-yl}-benzenesulfonamide | N-{3-[4-hydroxy-1-(3-methyl-butyl)-2-oxo-1,2-dihydro-quinolin-3-yl]-1,1-dioxo-1,4-dihydro-1lambda*6*-benzo[1,2,4]thiadiazin-7-yl}-benzenesulfonamide |
Type | Small organic molecule |
Emp. Form. | C26H25N5O6S2 |
Mol. Mass. | 567.637 |
SMILES | CC(C)CCn1c2ncccc2c(O)c(C2=Nc3ccc(NS(=O)(=O)c4ccccc4)cc3S(=O)(=O)N2)c1=O |t:16| |
Structure |
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