Reaction Details |
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Target | Histamine H3 receptor |
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Ligand | BDBM50186281 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_370710 (CHEMBL867233) |
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Ki | 2.1±n/a nM |
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Citation | Jesudason, CD; Beavers, LS; Cramer, JW; Dill, J; Finley, DR; Lindsley, CW; Stevens, FC; Gadski, RA; Oldham, SW; Pickard, RT; Siedem, CS; Sindelar, DK; Singh, A; Watson, BM; Hipskind, PA Synthesis and SAR of novel histamine H3 receptor antagonists. Bioorg Med Chem Lett16:3415-8 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Histamine H3 receptor |
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Name: | Histamine H3 receptor |
Synonyms: | G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4) |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 48691.47 |
Organism: | Homo sapiens (Human) |
Description: | Binding assays were using CHO cells stably expressing hH3R receptors. |
Residue: | 445 |
Sequence: | MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV
ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTS
SAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGG
SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAA
GPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSV
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSL
AVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFR
RAFTKLLCPQKLKIQPHSSLEHCWK
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BDBM50186281 |
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n/a |
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Name | BDBM50186281 |
Synonyms: | (6-(3-(piperidin-1-yl)propoxy)-3,4-dihydroisoquinolin-2(1H)-yl)(thiophen-2-yl)methanone | CHEMBL377099 |
Type | Small organic molecule |
Emp. Form. | C22H28N2O2S |
Mol. Mass. | 384.535 |
SMILES | O=C(N1CCc2cc(OCCCN3CCCCC3)ccc2C1)c1cccs1 |
Structure |
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