| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase 9 |
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| Ligand | BDBM50186373 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_365590 (CHEMBL870945) |
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| IC50 | 2.5±n/a nM |
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| Citation |  Shimamura, T; Shibata, J; Kurihara, H; Mita, T; Otsuki, S; Sagara, T; Hirai, H; Iwasawa, Y Identification of potent 5-pyrimidinyl-2-aminothiazole CDK4, 6 inhibitors with significant selectivity over CDK1, 2, 5, 7, and 9. Bioorg Med Chem Lett16:3751-4 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-dependent kinase 9 |
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| Name: | Cyclin-dependent kinase 9 |
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| Synonyms: | C-2K | CDC2L4 | CDK9 | CDK9_HUMAN | Cell division cycle 2-like protein kinase 4 | Cell division protein kinase 9 | Cyclin-Dependent Kinase 9 (CDK9) | Cyclin-dependent kinase 9 (CDK9) | Serine/threonine-protein kinase PITALRE | TAK | Tat-associated kinase complex catalytic subunit |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 42789.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 372 |
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| Sequence: | MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFP
ITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK
FTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNS
QPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLAL
ISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDP
AQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNP
ATTNQTEFERVF
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| BDBM50186373 |
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| n/a |
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| Name | BDBM50186373 |
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| Synonyms: | CHEMBL424696 | N-(5-(2-(cyclohexyloxy)pyrimidin-4-yl)thiazol-2-yl)pyridin-2-amine |
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| Type | Small organic molecule |
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| Emp. Form. | C18H19N5OS |
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| Mol. Mass. | 353.441 |
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| SMILES | C1CCC(CC1)Oc1nccc(n1)-c1cnc(Nc2ccccn2)s1 |
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| Structure | 
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