Reaction Details |
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Target | Cyclin-dependent kinase 4 |
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Ligand | BDBM50186374 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_365584 (CHEMBL870933) |
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IC50 | 13±n/a nM |
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Citation | Shimamura, T; Shibata, J; Kurihara, H; Mita, T; Otsuki, S; Sagara, T; Hirai, H; Iwasawa, Y Identification of potent 5-pyrimidinyl-2-aminothiazole CDK4, 6 inhibitors with significant selectivity over CDK1, 2, 5, 7, and 9. Bioorg Med Chem Lett16:3751-4 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cyclin-dependent kinase 4 |
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Name: | Cyclin-dependent kinase 4 |
Synonyms: | CDK4 | CDK4_HUMAN | Cell division protein kinase 4 | Cyclin-dependent kinase 4 (CDK 4) | PSK-J3 |
Type: | Enzyme Subunit |
Mol. Mass.: | 33731.96 |
Organism: | Homo sapiens (Human) |
Description: | P11802 |
Residue: | 303 |
Sequence: | MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL
RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL
MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWY
RAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR
DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEG
NPE
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BDBM50186374 |
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n/a |
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Name | BDBM50186374 |
Synonyms: | CHEMBL212049 | N-(5-(2-(cyclohexyloxy)-5-methylpyrimidin-4-yl)thiazol-2-yl)pyridin-2-amine |
Type | Small organic molecule |
Emp. Form. | C19H21N5OS |
Mol. Mass. | 367.468 |
SMILES | Cc1cnc(OC2CCCCC2)nc1-c1cnc(Nc2ccccn2)s1 |
Structure |
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