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TargetTyrosine-protein kinase ITK/TSK
LigandBDBM50186455
Substrate/Competitorn/a
Meas. Tech.ChEMBL_377329 (CHEMBL864159)
IC50 7070±n/a nM
Citation Das, JFurch, JALiu, CMoquin, RVLin, JSpergel, SHMcIntyre, KWShuster, DJO'Day, KDPenhallow, BHung, CYDoweyko, AMKamath, AZhang, HMarathe, PKanner, SBLin, TADodd, JHBarrish, JCWityak, J Discovery and SAR of 2-amino-5-(thioaryl)thiazoles as potent and selective Itk inhibitors. Bioorg Med Chem Lett16:3706-12 (2006) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Tyrosine-protein kinase ITK/TSK
Name:Tyrosine-protein kinase ITK/TSK
Synonyms:EMT | ITK | ITK_HUMAN | Kinase EMT | LYK | T-cell-specific kinase | Tyrosine-protein kinase ITK | Tyrosine-protein kinase ITK (ITK) | Tyrosine-protein kinase Lyk
Type:Protein
Mol. Mass.:71839.20
Organism:Homo sapiens (Human)
Description:Q08881
Residue:620
Sequence:
MNNFILLEEQLIKKSQQKRRTSPSNFKVRFFVLTKASLAYFEDRHGKKRTLKGSIELSRI
KCVEIVKSDISIPCHYKYPFQVVHDNYLLYVFAPDRESRQRWVLALKEETRNNNSLVPKY
HPNFWMDGKWRCCSQLEKLATGCAQYDPTKNASKKPLPPTPEDNRRPLWEPEETVVIALY
DYQTNDPQELALRRNEEYCLLDSSEIHWWRVQDRNGHEGYVPSSYLVEKSPNNLETYEWY
NKSISRDKAEKLLLDTGKEGAFMVRDSRTAGTYTVSVFTKAVVSENNPCIKHYHIKETND
NPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRLRYPVCFGRQKAPVTAGLRYGKWVIDP
SELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQ
LYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACVIH
RDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSD
VWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPE
DRPAFSRLLRQLAEIAESGL
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  Blast E-value cutoff:
BDBM50186455
n/a
NameBDBM50186455
Synonyms:1-(4-(3-(2-(thiazol-2-ylamino)thiazol-5-ylthio)benzoyl)piperazin-1-yl)ethanone | CHEMBL208541
TypeSmall organic molecule
Emp. Form.C19H19N5O2S3
Mol. Mass.445.581
SMILESCC(=O)N1CCN(CC1)C(=O)c1cccc(Sc2cnc(Nc3nccs3)s2)c1
Structure
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