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TargetTyrosine-protein kinase ITK/TSK
LigandBDBM50186492
Substrate/Competitorn/a
Meas. Tech.ChEMBL_377329 (CHEMBL864159)
IC50 600±n/a nM
Citation Das, JFurch, JALiu, CMoquin, RVLin, JSpergel, SHMcIntyre, KWShuster, DJO'Day, KDPenhallow, BHung, CYDoweyko, AMKamath, AZhang, HMarathe, PKanner, SBLin, TADodd, JHBarrish, JCWityak, J Discovery and SAR of 2-amino-5-(thioaryl)thiazoles as potent and selective Itk inhibitors. Bioorg Med Chem Lett16:3706-12 (2006) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Tyrosine-protein kinase ITK/TSK
Name:Tyrosine-protein kinase ITK/TSK
Synonyms:EMT | ITK | ITK_HUMAN | Kinase EMT | LYK | T-cell-specific kinase | Tyrosine-protein kinase ITK | Tyrosine-protein kinase ITK (ITK) | Tyrosine-protein kinase Lyk
Type:Protein
Mol. Mass.:71839.20
Organism:Homo sapiens (Human)
Description:Q08881
Residue:620
Sequence:
MNNFILLEEQLIKKSQQKRRTSPSNFKVRFFVLTKASLAYFEDRHGKKRTLKGSIELSRI
KCVEIVKSDISIPCHYKYPFQVVHDNYLLYVFAPDRESRQRWVLALKEETRNNNSLVPKY
HPNFWMDGKWRCCSQLEKLATGCAQYDPTKNASKKPLPPTPEDNRRPLWEPEETVVIALY
DYQTNDPQELALRRNEEYCLLDSSEIHWWRVQDRNGHEGYVPSSYLVEKSPNNLETYEWY
NKSISRDKAEKLLLDTGKEGAFMVRDSRTAGTYTVSVFTKAVVSENNPCIKHYHIKETND
NPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRLRYPVCFGRQKAPVTAGLRYGKWVIDP
SELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQ
LYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACVIH
RDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSD
VWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPE
DRPAFSRLLRQLAEIAESGL
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  Blast E-value cutoff:
BDBM50186492
n/a
NameBDBM50186492
Synonyms:CHEMBL373513 | N-(5-(3-(1-acetylpiperazine-4-carbonyl)-4-chlorophenylthio)thiazol-2-yl)-4-(dimethylamino)benzamide
TypeSmall organic molecule
Emp. Form.C25H26ClN5O3S2
Mol. Mass.544.089
SMILESCN(C)c1ccc(cc1)C(=O)Nc1ncc(Sc2ccc(Cl)c(c2)C(=O)N2CCN(CC2)C(C)=O)s1
Structure
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