Reaction Details | |||
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Target | Substance-P receptor | ||
Ligand | BDBM50186523 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_377172 (CHEMBL869696) | ||
Ki | 0.5±n/a nM | ||
Citation | Wrobleski, ML; Reichard, GA; Paliwal, S; Shah, S; Tsui, HC; Duffy, RA; Lachowicz, JE; Morgan, CA; Varty, GB; Shih, NY Cyclobutane derivatives as potent NK1 selective antagonists. Bioorg Med Chem Lett16:3859-63 (2006) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Substance-P receptor | |||
Name: | Substance-P receptor | ||
Synonyms: | NK-1 receptor | NK-1R | NK1 Receptor | NK1R | NK1R_HUMAN | Neurokinin 1 receptor | Neurokinin-1 (NK-1) | Neuromedin-1 receptor (NK-1R) | SPR | TAC1R | TACR1 | Tachykinin receptor 1 | Tachykinin receptor 1 (NK1) | tachykinin | ||
Type: | G Protein-Coupled Receptor (GPCR) | ||
Mol. Mass.: | 46254.43 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P25103 | ||
Residue: | 407 | ||
Sequence: |
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BDBM50186523 | |||
n/a | |||
Name | BDBM50186523 | ||
Synonyms: | CHEMBL214194 | cis-3-(((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)methyl)-1-amino-N-methyl-3-phenylcyclobutanecarboxamide | ||
Type | Small organic molecule | ||
Emp. Form. | C23H24F6N2O2 | ||
Mol. Mass. | 474.4393 | ||
SMILES | CNC(=O)[C@]1(N)C[C@@](CO[C@H](C)c2cc(cc(c2)C(F)(F)F)C(F)(F)F)(C1)c1ccccc1 |wU:10.10,4.3,wD:4.4,7.7,(-.65,-7.07,;.66,-6.27,;2.02,-7.01,;2.05,-8.55,;3.34,-6.21,;4.64,-7.01,;4.44,-5.13,;3.36,-4.03,;2.05,-3.23,;.7,-3.96,;-.61,-3.16,;-.58,-1.62,;-1.97,-3.89,;-2.01,-5.44,;-3.37,-6.18,;-4.68,-5.37,;-4.63,-3.82,;-3.28,-3.09,;-5.94,-3.01,;-5.14,-1.7,;-6.76,-4.32,;-7.26,-2.2,;-3.41,-7.71,;-1.88,-7.75,;-4.96,-7.66,;-3.44,-9.25,;2.26,-5.11,;4.72,-3.29,;6.02,-4.1,;7.38,-3.37,;7.42,-1.83,;6.09,-1.02,;4.75,-1.76,)| | ||
Structure |