Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Neuromedin-K receptor | ||
| Ligand | BDBM50186527 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_377175 (CHEMBL869705) | ||
| Ki | 4051±n/a nM | ||
| Citation |  Wrobleski, ML; Reichard, GA; Paliwal, S; Shah, S; Tsui, HC; Duffy, RA; Lachowicz, JE; Morgan, CA; Varty, GB; Shih, NY Cyclobutane derivatives as potent NK1 selective antagonists. Bioorg Med Chem Lett16:3859-63 (2006) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Neuromedin-K receptor | |||
| Name: | Neuromedin-K receptor | ||
| Synonyms: | NK-3 receptor | NK-3R | NK3R | NK3R_HUMAN | NKR | Neurokinin 3 receptor | Neurokinin B receptor | Neurokinin-3 (NK-3) | Neuromedin-3 receptor (NK-3R) | Neuromedin-3 receptor (NK3) | Neuromedin-K receptor | Neuromedin-K receptor (NK-3 receptor) | Neuromedin-K receptor (NK3) | Neuromedin-K receptor(NK3R) | TAC3R | TACR3 | Tachykinin receptor 3 | Tachykinin receptor 3 (NK3) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 52221.96 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P29371 | ||
| Residue: | 465 | ||
| Sequence: |
| ||
| BDBM50186527 | |||
| n/a | |||
| Name | BDBM50186527 | ||
| Synonyms: | (R)-3-((1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)methyl)-3-phenylcyclobutanamine | CHEMBL212428 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H21F6NO | ||
| Mol. Mass. | 417.388 | ||
| SMILES | C[C@@H](OCC1(CC(N)C1)c1ccccc1)c1cc(cc(c1)C(F)(F)F)C(F)(F)F |wU:1.0,(-2.49,.49,;-2.49,-1.05,;-1.15,-1.81,;.18,-1.04,;1.52,-1.8,;.45,-2.91,;1.56,-3.98,;1.59,-5.52,;2.63,-2.87,;2.86,-1.02,;4.18,-1.79,;5.51,-1.03,;5.51,.51,;4.18,1.27,;2.85,.51,;-3.82,-1.82,;-5.15,-1.06,;-6.48,-1.83,;-6.48,-3.37,;-5.15,-4.14,;-3.81,-3.37,;-5.15,-5.68,;-6.7,-5.67,;-3.62,-5.68,;-5.14,-7.22,;-7.82,-1.06,;-7.05,.28,;-8.59,-2.39,;-9.15,-.29,)| | ||
| Structure | 
| ||