Ki Summary

Reaction Details

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Target

Beta-glucosidase

Ligand

BDBM50186733

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_353428 (CHEMBL870034)

6.8±n/a

>1000000±n/a nM

Comments

extracted

Citation

Wang, RW; Qiu, XL; Bols, M; Ortega-Caballero, F; Qing, FL Synthesis and biological evaluation of glycosidase inhibitors: gem-difluoromethylenated nojirimycin analogues. J Med Chem49:2989-97 (2006) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Beta-glucosidase

Name:

Beta-glucosidase

Synonyms:

BGLS_WICAO

Type:

PROTEIN

Mol. Mass.:

89534.43

Organism:

Hansenula anomala

Description:

ChEMBL_353428

Residue:

825

Sequence:

MLLPLYGLASFLVLSQAALVNTSAPQASNDDPFNHSPSFYPTPQGGRINDGKWQAAFYRA
RELVDQMSIAEKVNLTTGVGSASGPCSGNTGSVPRLNISSICVQDGPLSVRAADLTDVFP
CGMAASSSFNKQLIYDRAVAIGSEFKGKGADAILGPVYGPMGVKAAGGRGWEGHGPDPYL
EGVIAYLQTIGIQSQGVVSTAKHLIGNEQEHFRFAKKDKHAGKIDPGMFNTSSSLSSEID
DRAMHEIYLWPFAEAVRGGVSSIMCSYNKLNGSHACQNSYLLNYLLKEELGFQGFVMTDW
GALYSGIDAANAGLDMDMPCEAQYFGGNLTTAVLNGTLPQDRLDDMATRILSALIYSGVH
NPDGPNYNAQTFLTEGHEYFKQQEGDIVVLNKHVDVRSDINRAVALRSAVEGVVLLKNEH
ETLPLGREKVKRISILGQAAGDDSKGTSCSLRGCGSGAIGTGYGSGAGTFSYFVTPADGI
GARAQQEKISYEFIGDSWNQAAAMDSALYADAAIEVANSVAGEEIGDVDGNYGDLNNLTL
WHNAVPLIKNISSINNNTIVIVTSGQQIDLEPFIDNENVTAVIYSSYLGQDFGTVLAKVL
FGDENPSGKLPFTIAKDVNDYIPVIEKVDVPDPVDKFTESIYVDYRYFDKYNKPVRYEFG
YGLSYSNFSLSDIEIQTLQPFSENAEPAANYSETYQYKQSNMDPSEYTVPEGFKELANYT
YPYIHDASSIKANSSYDYPEGYSTEQLDGPKSLAAGGLGGNHTCGMLVTLSLLKSQIKVL
MLVGLHLNCMLDIQIMMNSQHLQCNYVDLKRCFWIKIILKLFLLN

BDBM50186733

n/a

Name

BDBM50186733

Synonyms:

CHEMBL208152 | L-1,4,6-trideoxy-4,4-difluoronojirimycin

Type

Small organic molecule

Emp. Form.

C6H11F2NO2

Mol. Mass.

167.1538

SMILES

C[C@@H]1NC[C@@H](O)[C@H](O)C1(F)F

Structure