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TargetMelanin-concentrating hormone receptor 1
LigandBDBM50186849
Substrate/Competitorn/a
Meas. Tech.ChEMBL_376573 (CHEMBL866622)
Ki 10±n/a nM
Citation Wu, WLBurnett, DACaplen, MADomalski, MSBennett, CGreenlee, WJHawes, BEO'Neill, KWeig, BWeston, DSpar, BKowalski, T Design and synthesis of orally efficacious benzimidazoles as melanin-concentrating hormone receptor 1 antagonists. Bioorg Med Chem Lett16:3674-8 (2006) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Melanin-concentrating hormone receptor 1
Name:Melanin-concentrating hormone receptor 1
Synonyms:G-protein coupled receptor 24 | GPR24 | MCH receptor 1 | MCH-1R | MCH-R1 | MCHR | MCHR-1 | MCHR1 | MCHR1_HUMAN | Melanin Concentrating Hormone 1 | Melanin-Concentrating Hormone Receptor 1 (MCH1R) | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 1 (MCH-1) | Melanin-concentrating hormone receptor 1 (MCH1) | Melanin-concentrating hormone receptor 1 (MCHR-1) | Melanin-concentrating hormone receptor 1 (MCHR1) | SLC-1 | SLC1 | Somatostatin receptor-like protein
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:45976.27
Organism:Homo sapiens (Human)
Description:Membranes from CHO-K1 cells stably expressing human MCH1R were used in assays.
Residue:422
Sequence:
MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARL
WEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTIC
LLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHF
GETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALS
FISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRI
LQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVY
LYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESK
GT
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50186849
n/a
NameBDBM50186849
Synonyms:5-{4-[(1-cyclopropylmethyl-piperidin-4-ylidene)-(5-fluoro-6-trifluoromethyl-1H-benzoimidazol-2-yl)-methyl]-phenyl}-nicotinonitrile | CHEMBL377372
TypeSmall organic molecule
Emp. Form.C30H25F4N5
Mol. Mass.531.5466
SMILESFc1cc2[nH]c(nc2cc1C(F)(F)F)C(=C1CCN(CC2CC2)CC1)c1ccc(cc1)-c1cncc(c1)C#N |(27.19,2.64,;26.42,1.3,;24.89,1.3,;24.13,-.03,;22.62,-.35,;22.46,-1.88,;23.87,-2.51,;24.89,-1.36,;26.42,-1.36,;27.19,-.03,;28.73,-.03,;30.27,-.03,;28.73,-1.57,;28.73,1.51,;21.13,-2.65,;21.13,-4.19,;19.79,-4.95,;19.79,-6.49,;21.12,-7.26,;21.12,-8.8,;19.78,-9.57,;18.25,-9.57,;19.02,-10.91,;22.46,-6.49,;22.46,-4.95,;19.79,-1.88,;18.46,-2.66,;17.12,-1.89,;17.13,-.34,;18.46,.43,;19.79,-.34,;15.79,.43,;14.47,-.34,;13.14,.42,;13.13,1.97,;14.47,2.74,;15.8,1.97,;14.47,4.29,;14.47,5.83,)|
Structure
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