| Reaction Details |
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 | Report a problem with these data |
| Target | Melanocortin receptor 4 |
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| Ligand | BDBM50186868 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_376512 (CHEMBL869042) |
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| Ki | 6.8±n/a nM |
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| Citation |  Kuklish, SL; Backer, RT; Briner, K; Doecke, CW; Husain, S; Mullaney, JT; Ornstein, PL; Zgombick, JM; O'Brien, TP; Fisher, MJ Privileged structure based ligands for melanocortin receptors--4,4-disubstituted piperidine derivatives. Bioorg Med Chem Lett16:3843-6 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Melanocortin receptor 4 |
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| Name: | Melanocortin receptor 4 |
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| Synonyms: | MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R) |
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| Type: | Enzyme |
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| Mol. Mass.: | 36949.50 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P32245 |
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| Residue: | 332 |
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| Sequence: | MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLL
ENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVN
IDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVS
GILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGAN
MKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPL
IYALRSQELRKTFKEIICCYPLGGLCDLSSRY
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| BDBM50186868 |
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| n/a |
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| Name | BDBM50186868 |
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| Synonyms: | CHEMBL213340 | N-{(R)-1-(4-chloro-benzyl)-2-[4-(4-cyclohexylmethyl-1-methyl-piperidin-4-yl)-piperazin-1-yl]-2-oxo-ethyl}-2-(2,3-dihydro-1H-isoindol-1-yl)-acetamide trifluoroacetic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C36H50ClN5O2 |
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| Mol. Mass. | 620.267 |
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| SMILES | CN1CCC(CC2CCCCC2)(CC1)N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)CC1NCc2ccccc12 |
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| Structure | 
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