| Reaction Details |
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 | Report a problem with these data |
| Target | Dimer of Tryptase beta-2 |
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| Ligand | BDBM50187166 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_387229 (CHEMBL864198) |
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| Ki | 1.7±n/a nM |
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| Citation |  Lee, CS; Liu, W; Sprengeler, PA; Somoza, JR; Janc, JW; Sperandio, D; Spencer, JR; Green, MJ; McGrath, ME Design of novel, potent, and selective human beta-tryptase inhibitors based on alpha-keto-[1,2,4]-oxadiazoles. Bioorg Med Chem Lett16:4036-40 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dimer of Tryptase beta-2 |
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| Name: | Dimer of Tryptase beta-2 |
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| Synonyms: | Tryptase beta-1/beta-2 |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of EBI is 365130 |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Tryptase beta-2 |
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| Synonyms: | TPS2 | TPSB2 | TRYB2_HUMAN | Tryptase | Tryptase II | Tryptase beta-1 | Tryptase-2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 30518.79 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_210702 |
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| Residue: | 275 |
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| Sequence: | MLNLLLLALPVLASRAYAAPAPGQALQRVGIVGGQEAPRSKWPWQVSLRVHGPYWMHFCG
GSLIHPQWVLTAAHCVGPDVKDLAALRVQLREQHLYYQDQLLPVSRIIVHPQFYTAQIGA
DIALLELEEPVNVSSHVHTVTLPPASETFPPGMPCWVTGWGDVDNDERLPPPFPLKQVKV
PIMENHICDAKYHLGAYTGDDVRIVRDDMLCAGNTRRDSCQGDSGGPLVCKVNGTWLQAG
VVSWGEGCAQPNRPGIYTRVTYYLDWIHHYVPKKP
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| Component 2 |
| Name: | Tryptase beta-2 |
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| Synonyms: | TPS2 | TPSB2 | TRYB2_HUMAN | Tryptase | Tryptase II | Tryptase beta-1 | Tryptase-2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 30518.79 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_210702 |
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| Residue: | 275 |
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| Sequence: | MLNLLLLALPVLASRAYAAPAPGQALQRVGIVGGQEAPRSKWPWQVSLRVHGPYWMHFCG
GSLIHPQWVLTAAHCVGPDVKDLAALRVQLREQHLYYQDQLLPVSRIIVHPQFYTAQIGA
DIALLELEEPVNVSSHVHTVTLPPASETFPPGMPCWVTGWGDVDNDERLPPPFPLKQVKV
PIMENHICDAKYHLGAYTGDDVRIVRDDMLCAGNTRRDSCQGDSGGPLVCKVNGTWLQAG
VVSWGEGCAQPNRPGIYTRVTYYLDWIHHYVPKKP
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| BDBM50187166 |
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| n/a |
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| Name | BDBM50187166 |
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| Synonyms: | CHEMBL380293 | N-[(S)-5-amino-1-(5-{4-[2-(3-chloro-phenyl)-ethylcarbamoyl]-benzyl}-[1,2,4]oxadiazole-3-carbonyl)-pentyl]-3,4-difluoro-benzamide |
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| Type | Small organic molecule |
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| Emp. Form. | C31H30ClF2N5O4 |
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| Mol. Mass. | 610.051 |
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| SMILES | NCCCC[C@H](NC(=O)c1ccc(F)c(F)c1)C(=O)c1noc(Cc2ccc(cc2)C(=O)NCCc2cccc(Cl)c2)n1 |
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| Structure | 
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