| Reaction Details |
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 | Report a problem with these data |
| Target | Integrase |
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| Ligand | BDBM50187771 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_378127 (CHEMBL869776) |
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| IC50 | 7.2±n/a nM |
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| Citation |  Metobo, SE; Jin, H; Tsiang, M; Kim, CU Design, synthesis, and biological evaluation of novel tricyclic HIV-1 integrase inhibitors by modification of its pyridine ring. Bioorg Med Chem Lett16:3985-8 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Integrase |
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| Name: | Integrase |
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| Synonyms: | Human immunodeficiency virus type 1 integrase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 32231.48 |
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| Organism: | Human immunodeficiency virus 1 |
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| Description: | ChEMBL_90865 |
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| Residue: | 288 |
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| Sequence: | FLDGIDKAQDEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSN
FTSTTVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGDDCVASRQDED
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| BDBM50187771 |
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| n/a |
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| Name | BDBM50187771 |
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| Synonyms: | 7-(4-fluorobenzyl)-3-fluoro-9-hydroxy-5-methoxy-6,7-dihydropyrrolo[3,4-g]quinolin-8-one | CHEMBL212213 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H14F2N2O3 |
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| Mol. Mass. | 356.3229 |
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| SMILES | COc1c2CN(Cc3ccc(F)cc3)C(=O)c2c(O)c2ncc(F)cc12 |
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| Structure | 
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