| Reaction Details |
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 | Report a problem with these data |
| Target | Tryptase |
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| Ligand | BDBM50187800 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_385584 (CHEMBL869805) |
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| Ki | 5.5±n/a nM |
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| Citation |  Sperandio, D; Tai, VW; Lohman, J; Hirschbein, B; Mendonca, R; Lee, CS; Spencer, JR; Janc, J; Nguyen, M; Beltman, J; Sprengeler, P; Scheerens, H; Lin, T; Liu, L; Gadre, A; Kellogg, A; Green, MJ; McGrath, ME Novel, potent, selective, and orally bioavailable human betaII-tryptase inhibitors. Bioorg Med Chem Lett16:4085-9 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tryptase |
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| Name: | Tryptase |
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| Synonyms: | Mcp7 | Mcpt7 | TRYB1_RAT | Tpsab1 | Tpsb1 | Tryptase alpha/beta-1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 30399.92 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_385584 |
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| Residue: | 273 |
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| Sequence: | MLKLLLLTLPLLSSLVHAAPSLAMPREGIVGGQEASGNKWPWQVSLRVNDTYWMHFCGGS
LIHPQWVLTAAHCVGPNKADPNKLRVQLRKQYLYYHDHLLTVSQIISHPDFYIAQDGADI
ALLKLTNPVNITSNVHTVSLPPASETFPSGTLCWVTGWGNINNDVSLPPPFPLEEVQVPI
VENRLCDLKYHKGLNTGDNVHIVRDDMLCAGNEGHDSCQGDSGGPLVCKVEDTWLQAGVV
SWGEGCAQPNRPGIYTRVTYYLDWIYRYVPKYF
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| BDBM50187800 |
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| n/a |
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| Name | BDBM50187800 |
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| Synonyms: | (S)-ethyl 1-(5-(4-phenethoxybenzyl)-1,2,4-oxadiazol-3-yl)-6-amino-1-oxohexan-2-ylcarbamate | CHEMBL211561 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H32N4O5 |
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| Mol. Mass. | 480.5561 |
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| SMILES | CCOC(=O)N[C@@H](CCCCN)C(=O)c1noc(Cc2ccc(OCCc3ccccc3)cc2)n1 |
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| Structure | 
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