Reaction Details |
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Target | Mu-type opioid receptor |
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Ligand | BDBM50188156 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_379863 (CHEMBL864851) |
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IC50 | 2±n/a nM |
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Citation | Nefzi, A; Ostresh, JM; Appel, JR; Bidlack, J; Dooley, CT; Houghten, RA Identification of potent and highly selective chiral tri-amine and tetra-amine mu opioid receptors ligands: an example of lead optimization using mixture-based libraries. Bioorg Med Chem Lett16:4331-8 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Mu-type opioid receptor |
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Name: | Mu-type opioid receptor |
Synonyms: | M-OR-1 | MOR-1 | Mu opioid receptor | Mu-type opioid receptor (Mu) | OPIATE Mu | OPRM1 | OPRM_CAVPO |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 11165.58 |
Organism: | GUINEA PIG |
Description: | P97266 |
Residue: | 98 |
Sequence: | YTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSI
FTLCTMSVDRYIAVCHPVKALDFRTPRNAKTVNVCNWI
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BDBM50188156 |
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n/a |
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Name | BDBM50188156 |
Synonyms: | 4-[(2S)-3-{[(2S)-1-(4-hydroxyphenyl)-3-{methyl[(2S)-1-[(2S)-2-[(methylamino)methyl]pyrrolidin-1-yl]-3-phenylpropan-2-yl]amino}propan-2-yl](methyl)amino}-2-(methylamino)propyl]phenol | CHEMBL215595 |
Type | Small organic molecule |
Emp. Form. | C36H53N5O2 |
Mol. Mass. | 587.8383 |
SMILES | CNC[C@@H]1CCCN1C[C@H](Cc1ccccc1)N(C)C[C@H](Cc1ccc(O)cc1)N(C)C[C@H](Cc1ccc(O)cc1)NC |
Structure |
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