| Reaction Details |
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 | Report a problem with these data |
| Target | Cathepsin K |
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| Ligand | BDBM50188296 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_379266 (CHEMBL853454) |
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| Ki | 1.3±n/a nM |
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| Citation |  Setti, EL; Venkatraman, S; Palmer, JT; Xie, X; Cheung, H; Yu, W; Wesolowski, G; Robichaud, J Design and synthesis of tetracyclic nonpeptidic biaryl nitrile inhibitors of cathepsin K. Bioorg Med Chem Lett16:4296-9 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cathepsin K |
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| Name: | Cathepsin K |
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| Synonyms: | CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X |
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| Type: | Enzyme |
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| Mol. Mass.: | 36975.68 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P43235 |
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| Residue: | 329 |
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| Sequence: | MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIH
NLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVD
YRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGG
YMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVA
RVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGE
NWGNKGYILMARNKNNACGIANLASFPKM
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| BDBM50188296 |
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| n/a |
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| Name | BDBM50188296 |
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| Synonyms: | (R)-2-{3'-[2-(4-tert-butyl-piperazin-1-yl)-thiazol-4-yl]-biphenyl-3-yl}-4-methyl-pentanoic acid cyanomethyl-amide | CHEMBL212879 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H39N5OS |
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| Mol. Mass. | 529.739 |
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| SMILES | CC(C)C[C@@H](C(=O)NCC#N)c1cccc(c1)-c1cccc(c1)-c1csc(n1)N1CCN(CC1)C(C)(C)C |
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| Structure | 
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