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TargetProstaglandin D2 receptor 2
LigandBDBM50188313
Substrate/Competitorn/a
Meas. Tech.ChEMBL_378634 (CHEMBL868656)
IC50 21±n/a nM
Citation Birkinshaw, TN; Teague, SJ; Beech, C; Bonnert, RV; Hill, S; Patel, A; Reakes, S; Sanganee, H; Dougall, IG; Phillips, TT; Salter, S; Schmidt, J; Arrowsmith, EC; Carrillo, JJ; Bell, FM; Paine, SW; Weaver, R Discovery of potent CRTh2 (DP2) receptor antagonists. Bioorg Med Chem Lett16:4287-90 (2006) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Prostaglandin D2 receptor 2
Name:Prostaglandin D2 receptor 2
Synonyms:CD_antigen=CD294 | CRTH2 | Chemoattractant Receptor-homologous molecule expressed on T-helper type 2 cells (CRTH2) | Chemoattractant receptor-homologous molecule expressed on Th2 cells | Chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) | DL1R | G protein-coupled receptor 44 | G-protein coupled receptor 44 | GPR44 | PD2R2_HUMAN | PTGDR2 | Prostaglandin D2 | Prostaglandin D2 receptor 2 | Prostaglandin D2 receptor 2 (PGD2)
Type:Enzyme
Mol. Mass.:43295.45
Organism:Homo sapiens (Human)
Description:Q9Y5Y4
Residue:395
Sequence:
MSANATLKPLCPILEQMSRLQSHSNTSIRYIDHAAVLLHGLASLLGLVENGVILFVVGCR
MRQTVVTTWVLHLALSDLLASASLPFFTYFLAVGHSWELGTTFCKLHSSIFFLNMFASGF
LLSAISLDRCLQVVRPVWAQNHRTVAAAHKVCLVLWALAVLNTVPYFVFRDTISRLDGRI
MCYYNVLLLNPGPDRDATCNSRQVALAVSKFLLAFLVPLAIIASSHAAVSLRLQHRGRRR
PGRFVRLVAAVVAAFALCWGPYHVFSLLEARAHANPGLRPLVWRGLPFVTSLAFFNSVAN
PVLYVLTCPDMLRKLRRSLRTVLESVLVDDSELGGAGSSRRRRTSSTARSASPLALCSRP
EEPRGPARLLGWLLGSCAASPQTGPLNRALSSTSS
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  Blast E-value cutoff:
BDBM50188313
n/a
NameBDBM50188313
Synonyms:2-(2,5-dimethyl-3-(quinolin-4-yl)-1H-indol-1-yl)acetic acid | CHEMBL378666
TypeSmall organic molecule
Emp. Form.C21H18N2O2
Mol. Mass.330.3798
SMILESCc1c(-c2ccnc3ccccc23)c2cc(C)ccc2n1CC(O)=O |(12.8,-17.54,;11.26,-17.55,;10.36,-18.82,;10.84,-20.28,;12.34,-20.58,;12.83,-22.03,;11.81,-23.19,;10.3,-22.88,;9.29,-24.02,;7.79,-23.72,;7.3,-22.26,;8.32,-21.12,;9.82,-21.43,;8.87,-18.34,;7.54,-19.11,;6.2,-18.34,;4.87,-19.11,;6.21,-16.8,;7.53,-16.02,;8.87,-16.79,;10.35,-16.31,;10.82,-14.84,;12.32,-14.51,;13.36,-15.65,;12.8,-13.04,)|
Structure
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