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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | 17-beta-hydroxysteroid dehydrogenase type 1 | ||
| Ligand | BDBM50188387 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_362610 (CHEMBL853212) | ||
| IC50 | >30000±n/a nM | ||
| Citation |  Schuster, D; Maurer, EM; Laggner, C; Nashev, LG; Wilckens, T; Langer, T; Odermatt, A The discovery of new 11beta-hydroxysteroid dehydrogenase type 1 inhibitors by common feature pharmacophore modeling and virtual screening. J Med Chem49:3454-66 (2006) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| 17-beta-hydroxysteroid dehydrogenase type 1 | |||
| Name: | 17-beta-hydroxysteroid dehydrogenase type 1 | ||
| Synonyms: | 17-beta-HSD 1 | 17-beta-Hydroxysteroid Dehydrogenase 1 (17-beta-HSD1) | 17-beta-hydroxysteroid dehydrogenase type 1 | 20 alpha-hydroxysteroid dehydrogenase | 20-alpha-HSD | DHB1_HUMAN | E17KSR | E2DH | EDH17B1 | EDH17B2 | EDHB17 | Estradiol 17-beta-dehydrogenase 1 | Estradiol 17-beta-dehydrogenase 1 (17beta-HSD1) | HSD17B1 | Placental 17-beta-hydroxysteroid dehydrogenase | SDR28C1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 34945.13 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P14061 | ||
| Residue: | 328 | ||
| Sequence: |
| ||
| BDBM50188387 | |||
| n/a | |||
| Name | BDBM50188387 | ||
| Synonyms: | (2S,4aS,6aS,6bR,8aR,10S,12aS,12bR,14bR)-10-amino-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid | CHEMBL425772 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C30H47NO3 | ||
| Mol. Mass. | 469.6991 | ||
| SMILES | CC1(C)[C@@H](N)CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2C(=O)C=C2[C@@H]3C[C@](C)(CC[C@]3(C)CC[C@@]12C)C(O)=O |t:19| | ||
| Structure | 
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