Ki Summary

Reaction Details

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Target

Calcium/calmodulin-dependent protein kinase type II subunit alpha

Ligand

BDBM50188913

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_389607 (CHEMBL868614)

IC50

8000±n/a nM

Citation

Lin, X; Murray, JM; Rico, AC; Wang, MX; Chu, DT; Zhou, Y; Del Rosario, M; Kaufman, S; Ma, S; Fang, E; Crawford, K; Jefferson, AB Discovery of 2-pyrimidyl-5-amidothiophenes as potent inhibitors for AKT: synthesis and SAR studies. Bioorg Med Chem Lett16:4163-8 (2006) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Calcium/calmodulin-dependent protein kinase type II subunit alpha

Name:

Calcium/calmodulin-dependent protein kinase type II subunit alpha

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

54093.63

Organism:

Homo sapiens (Human)

Description:

gi_25952118

Residue:

478

Sequence:

MATITCTRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLERE
ARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQIL
EAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYL
SPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTV
TPEAKDLINKMLTINPSKRITAAEALKHPWISHRSTVASCMHRQETVDCLKKFNARRKLK
GAILTTMLATRNFSGGKSGGNKKSDGVKESSESTNTTIEDEDTKVRKQEIIKVTEQLIEA
ISNGDFESYTKMCDPGMTAFEPEALGNLVEGLDFHRFYFENLWSRNSKPVHTTILNPHIH
LMGDESACIAYIRITQYLDAGGIPRTAQSEETRVWHRRDGKWQIVHFHRSGAPSVLPH

BDBM50188913

n/a

Name

BDBM50188913

Synonyms:

CHEMBL213618 | N-((S)-1-amino-3-(2,4-dichlorophenyl)propan-2-yl)-5-(2-(methylamino)pyrimidin-4-yl)thiophene-2-carboxamide | N-[(1S)-2-AMINO-1-(2,4-DICHLOROBENZYL)ETHYL]-5-[2-(METHYLAMINO)PYRIMIDIN-4-YL]THIOPHENE-2-CARBOXAMIDE

Type

Small organic molecule

Emp. Form.

C19H19Cl2N5OS

Mol. Mass.

436.358

SMILES

CNc1nccc(n1)-c1ccc(s1)C(=O)N[C@H](CN)Cc1ccc(Cl)cc1Cl

Structure