| Reaction Details |
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 | Report a problem with these data |
| Target | Estrogen receptor beta |
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| Ligand | BDBM50189088 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_394398 (CHEMBL855874) |
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| IC50 | 11±n/a nM |
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| Citation |  Parker, DL; Meng, D; Ratcliffe, RW; Wilkening, RR; Sperbeck, DM; Greenlee, ML; Colwell, LF; Lambert, S; Birzin, ET; Frisch, K; Rohrer, SP; Nilsson, S; Thorsell, AG; Hammond, ML Triazolo-tetrahydrofluorenones as selective estrogen receptor beta agonists. Bioorg Med Chem Lett16:4652-6 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Estrogen receptor beta |
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| Name: | Estrogen receptor beta |
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| Synonyms: | ER-beta | ESR2 | ESR2_HUMAN | ESTRB | Estradiol receptor beta (ERβ) | Estrogen receptor | Estrogen receptor (ER beta) | Estrogen receptor beta | Estrogen receptor beta (ER beta) | Estrogen receptor beta (ER) | NR3A2 | Nuclear receptor subfamily 3 group A member 2 | estrogen beta |
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| Type: | Protein |
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| Mol. Mass.: | 59238.43 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q92731 |
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| Residue: | 530 |
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| Sequence: | MDIKNSPSSLNSPSSYNCSQSILPLEHGSIYIPSSYVDSHHEYPAMTFYSPAVMNYSIPS
NVTNLEGGPGRQTTSPNVLWPTPGHLSPLVVHRQLSHLYAEPQKSPWCEARSLEHTLPVN
RETLKRKVSGNRCASPVTGPGSKRDAHFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGH
NDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRLVRRQRSADEQLH
CAGKAKRSGGHAPRVRELLLDALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTK
LADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDL
VLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLVTATQDA
DSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMK
CKNVVPVYDLLLEMLNAHVLRGCKSSITGSECSPAEDSKSKEGSQNPQSQ
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| BDBM50189088 |
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| n/a |
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| Name | BDBM50189088 |
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| Synonyms: | 9a-ethyl-6-propyl-8,9,9a,10-tetrahydro-3H-1,2,3-triaza-cyclopenta[a]fluoren-7-one | CHEMBL378883 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H21N3O |
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| Mol. Mass. | 295.3788 |
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| SMILES | CCCC1=C2c3ccc4nn[nH]c4c3CC2(CC)CCC1=O |c:3| |
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| Structure | 
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