| Reaction Details |
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 | Report a problem with these data |
| Target | Melanin-concentrating hormone receptor 1 |
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| Ligand | BDBM50189578 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_368881 (CHEMBL865555) |
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| Ki | 1.9±n/a nM |
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| Citation |  Dyck, B; Markison, S; Zhao, L; Tamiya, J; Grey, J; Rowbottom, MW; Zhang, M; Vickers, T; Sorensen, K; Norton, C; Wen, J; Heise, CE; Saunders, J; Conlon, P; Madan, A; Schwarz, D; Goodfellow, VS A thienopyridazinone-based melanin-concentrating hormone receptor 1 antagonist with potent in vivo anorectic properties. J Med Chem49:3753-6 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Melanin-concentrating hormone receptor 1 |
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| Name: | Melanin-concentrating hormone receptor 1 |
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| Synonyms: | G-protein coupled receptor 24 | Gpr24 | MCH receptor 1 | MCH-1R | MCH-R1 | MCH1R | MCHR | MCHR-1 | MCHR1_RAT | Mchr1 | Melanin Concentrating Hormone 1 | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 1 | SLC-1 | Slc1 | Somatostatin receptor-like protein |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 39075.64 |
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| Organism: | RAT |
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| Description: | Melanin Concentrating Hormone 1 GPR24 RAT::P97639 |
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| Residue: | 353 |
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| Sequence: | MDLQTSLLSTGPNASNISDGQDNLTLPGSPPRTGSVSYINIIMPSVFGTICLLGIVGNST
VIFAVVKKSKLHWCSNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLIT
AMDANSQFTSTYILTAMTIDRYLATVHPISSTKFRKPSMATLVICLLWALSFISITPVWL
YARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVKILQRMTSSVA
PASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLG
YANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRTVSNAQTADEERTESKGT
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| BDBM50189578 |
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| n/a |
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| Name | BDBM50189578 |
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| Synonyms: | (R)-2-(4-chlorophenyl)-6-(6-(3-(methylamino)pyrrolidin-1-yl)pyridin-3-yl)thieno[2,3-d]pyridazin-7(6H)-one | CHEMBL377588 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H20ClN5OS |
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| Mol. Mass. | 437.945 |
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| SMILES | CN[C@@H]1CCN(C1)c1ccc(cn1)-n1ncc2cc(sc2c1=O)-c1ccc(Cl)cc1 |
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| Structure | 
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