| Reaction Details |
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 | Report a problem with these data |
| Target | Coagulation factor VII/Tissue factor |
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| Ligand | BDBM50189938 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_393411 (CHEMBL913194) |
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| Ki | 2.6±n/a nM |
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| Citation |  Hu, H; Kolesnikov, A; Riggs, JR; Wesson, KE; Stephens, R; Leahy, EM; Shrader, WD; Sprengeler, PA; Green, MJ; Sanford, E; Nguyen, M; Gjerstad, E; Cabuslay, R; Young, WB Potent 4-amino-5-azaindole factor VIIa inhibitors. Bioorg Med Chem Lett16:4567-70 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Coagulation factor VII/Tissue factor |
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| Name: | Coagulation factor VII/Tissue factor |
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| Synonyms: | Coagulation factor III/Factor VIIa (fVIIa) | Coagulation factor III/VII |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of EBI is 69535 |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Tissue factor |
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| Synonyms: | CD_antigen=CD142 | Coagulation factor III | Coagulation factor VII/tissue factor | F3 | TF | TF_HUMAN | Thromboplastin | Tissue factor |
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| Type: | PROTEIN |
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| Mol. Mass.: | 33067.61 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_936735 |
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| Residue: | 295 |
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| Sequence: | METPAWPRVPRPETAVARTLLLGWVFAQVAGASGTTNTVAAYNLTWKSTNFKTILEWEPK
PVNQVYTVQISTKSGDWKSKCFYTTDTECDLTDEIVKDVKQTYLARVFSYPAGNVESTGS
AGEPLYENSPEFTPYLETNLGQPTIQSFEQVGTKVNVTVEDERTLVRRNNTFLSLRDVFG
KDLIYTLYYWKSSSSGKKTAKTNTNEFLIDVDKGENYCFSVQAVIPSRTVNRKSTDSPVE
CMGQEKGEFREIFYIIGAVVFVVIILVIILAISLHKCRKAGVGQSWKENSPLNVS
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| Component 2 |
| Name: | Coagulation factor VII |
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| Synonyms: | Eptacog alfa | F7 | FA7_HUMAN | Factor VIIa | Factor VIIa (fVIIa) | Proconvertin | SPCA | Thrombin and coagulation factor VII | serum prothrombin conversion accelerator |
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| Type: | Enzyme |
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| Mol. Mass.: | 51599.89 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 466 |
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| Sequence: | MVSQALRLLCLLLGLQGCLAAGGVAKASGGETRDMPWKPGPHRVFVTQEEAHGVLHRRRR
ANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGS
CKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSL
LADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGG
TLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTN
HDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVL
NVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTG
IVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP
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| BDBM50189938 |
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| n/a |
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| Name | BDBM50189938 |
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| Synonyms: | 2-{5-(4-amino-1H-pyrrolo[3,2-c]pyridin-2-yl)-3'-[3-(2,6-difluoro-phenyl)-ureidomethyl]-6-hydroxy-biphenyl-3-yl}-2-methyl-propionic acid | CHEMBL209946 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H27F2N5O4 |
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| Mol. Mass. | 571.574 |
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| SMILES | CC(C)(C(O)=O)c1cc(-c2cc3c(N)nccc3[nH]2)c(O)c(c1)-c1cccc(CNC(=O)Nc2c(F)cccc2F)c1 |
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| Structure | 
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