Reaction Details |
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Target | Carbonic anhydrase 2 |
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Ligand | BDBM50190246 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_400480 (CHEMBL912680) |
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Ki | 5570±n/a nM |
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Citation | Slawinski, F; Slawinski, J; Kornicka, A; Brzozowski, Z; Pomarnacka, E; Innocenti, A; Slawinski, A; Slawinski, CT Carbonic anhydrase inhibitors. Inhibition of the cytosolic human isozymes I and II, and the transmembrane, tumor-associated isozymes IX and XII with substituted aromatic sulfonamides activatable in hypoxic tumors. Bioorg Med Chem Lett16:4846-51 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Carbonic anhydrase 2 |
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Name: | Carbonic anhydrase 2 |
Synonyms: | CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II) |
Type: | Enzyme |
Mol. Mass.: | 29250.71 |
Organism: | Homo sapiens (Human) |
Description: | P00918 |
Residue: | 260 |
Sequence: | MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRIL
NNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHL
VHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDP
RGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELM
VDNWRPAQPLKNRQIKASFK
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BDBM50190246 |
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n/a |
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Name | BDBM50190246 |
Synonyms: | CHEMBL384791 | ethyl 2-chloro-4-{[5-chloro-4-(ethoxycarbonyl)-2-sulfamoylphenyl]disulfanyl}-5-sulfamoylbenzoate |
Type | Small organic molecule |
Emp. Form. | C18H18Cl2N2O8S4 |
Mol. Mass. | 589.51 |
SMILES | CCOC(=O)c1cc(c(SSc2cc(Cl)c(cc2S(N)(=O)=O)C(=O)OCC)cc1Cl)S(N)(=O)=O |
Structure |
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