| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Carbonic anhydrase 12 |
|---|
| Ligand | BDBM50190247 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_400482 (CHEMBL912682) |
|---|
| Ki | 1348±n/a nM |
|---|
| Citation |  Slawinski, F; Slawinski, J; Kornicka, A; Brzozowski, Z; Pomarnacka, E; Innocenti, A; Slawinski, A; Slawinski, CT Carbonic anhydrase inhibitors. Inhibition of the cytosolic human isozymes I and II, and the transmembrane, tumor-associated isozymes IX and XII with substituted aromatic sulfonamides activatable in hypoxic tumors. Bioorg Med Chem Lett16:4846-51 (2006) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Carbonic anhydrase 12 |
|---|
| Name: | Carbonic anhydrase 12 |
|---|
| Synonyms: | CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 39456.00 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Catalytic domain of human cloned isozyme was used in the assay |
|---|
| Residue: | 354 |
|---|
| Sequence: | MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDL
HSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHL
HWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFN
PSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFR
NPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGL
SLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
|
|
|
|---|
| BDBM50190247 |
|---|
| n/a |
|---|
| Name | BDBM50190247 |
|---|
| Synonyms: | (5-chloro-4-methyl-2-sulfamoyl-benzenesulfonyl)-acetic acid methyl ester | CHEMBL212811 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C10H12ClNO6S2 |
|---|
| Mol. Mass. | 341.788 |
|---|
| SMILES | COC(=O)CS(=O)(=O)c1cc(Cl)c(C)cc1S(N)(=O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
