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TargetCarbonic anhydrase 2
LigandBDBM50190240
Substrate/Competitorn/a
Meas. Tech.ChEMBL_400480 (CHEMBL912680)
Ki 536±n/a nM
Citation Slawinski, FSlawinski, JKornicka, ABrzozowski, ZPomarnacka, EInnocenti, ASlawinski, ASlawinski, CT Carbonic anhydrase inhibitors. Inhibition of the cytosolic human isozymes I and II, and the transmembrane, tumor-associated isozymes IX and XII with substituted aromatic sulfonamides activatable in hypoxic tumors. Bioorg Med Chem Lett16:4846-51 (2006) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Carbonic anhydrase 2
Name:Carbonic anhydrase 2
Synonyms:CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:Enzyme
Mol. Mass.:29250.71
Organism:Homo sapiens (Human)
Description:P00918
Residue:260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRIL
NNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHL
VHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDP
RGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELM
VDNWRPAQPLKNRQIKASFK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50190240
n/a
NameBDBM50190240
Synonyms:4-chloro-2-(1-hydrazinocarbonyl-ethanesulfonyl)-5-methyl-benzenesulfonamide | CHEMBL215276
TypeSmall organic molecule
Emp. Form.C10H14ClN3O5S2
Mol. Mass.355.818
SMILESCC(C(=O)NN)S(=O)(=O)c1cc(Cl)c(C)cc1S(N)(=O)=O
Structure
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