| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Carbonic anhydrase 2 |
|---|
| Ligand | BDBM50190255 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_400480 (CHEMBL912680) |
|---|
| Ki | >10000±n/a nM |
|---|
| Citation |  Slawinski, F; Slawinski, J; Kornicka, A; Brzozowski, Z; Pomarnacka, E; Innocenti, A; Slawinski, A; Slawinski, CT Carbonic anhydrase inhibitors. Inhibition of the cytosolic human isozymes I and II, and the transmembrane, tumor-associated isozymes IX and XII with substituted aromatic sulfonamides activatable in hypoxic tumors. Bioorg Med Chem Lett16:4846-51 (2006) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Carbonic anhydrase 2 |
|---|
| Name: | Carbonic anhydrase 2 |
|---|
| Synonyms: | CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 29250.71 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P00918 |
|---|
| Residue: | 260 |
|---|
| Sequence: | MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRIL
NNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHL
VHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDP
RGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELM
VDNWRPAQPLKNRQIKASFK
|
|
|
|---|
| BDBM50190255 |
|---|
| n/a |
|---|
| Name | BDBM50190255 |
|---|
| Synonyms: | 2-(aminosulfonyl)-5-chloro-4-methylphenyl N-(4-nitrophenyl)benzenecarbohydrazonothioate | CHEMBL385195 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H17ClN4O4S2 |
|---|
| Mol. Mass. | 476.956 |
|---|
| SMILES | Cc1cc(c(SC(=NNc2ccc(cc2)[N+]([O-])=O)c2ccccc2)cc1Cl)S(N)(=O)=O |w:7.7| |
|---|
| Structure | 
|
|---|
Search and Browse
