Reaction Details |
| Report a problem with these data |
Target | Malonyl-CoA decarboxylase, mitochondrial |
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Ligand | BDBM50190401 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_375433 (CHEMBL864146) |
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IC50 | 5±n/a nM |
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Citation | Cheng, JF; Huang, Y; Penuliar, R; Nishimoto, M; Liu, L; Arrhenius, T; Yang, G; O'leary, E; Barbosa, M; Barr, R; Dyck, JR; Lopaschuk, GD; Nadzan, AM Discovery of potent and orally available malonyl-CoA decarboxylase inhibitors as cardioprotective agents. J Med Chem49:4055-8 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Malonyl-CoA decarboxylase, mitochondrial |
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Name: | Malonyl-CoA decarboxylase, mitochondrial |
Synonyms: | DCMC_HUMAN | MLYCD | Malonyl-CoA decarboxylase |
Type: | PROTEIN |
Mol. Mass.: | 55018.37 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_665404 |
Residue: | 493 |
Sequence: | MRGFGPGLTARRLLPLRLPPRPPGPRLASGQAAGALERAMDELLRRAVPPTPAYELREKT
PAPAEGQCADFVSFYGGLAETAQRAELLGRLARGFGVDHGQVAEQSAGVLHLRQQQREAA
VLLQAEDRLRYALVPRYRGLFHHISKLDGGVRFLVQLRADLLEAQALKLVEGPDVREMNG
VLKGMLSEWFSSGFLNLERVTWHSPCEVLQKISEAEAVHPVKNWMDMKRRVGPYRRCYFF
SHCSTPGEPLVVLHVALTGDISSNIQAIVKEHPPSETEEKNKITAAIFYSISLTQQGLQG
VELGTFLIKRVVKELQREFPHLGVFSSLSPIPGFTKWLLGLLNSQTKEHGRNELFTDSEC
KEISEITGGPINETLKLLLSSSEWVQSEKLVRALQTPLMRLCAWYLYGEKHRGYALNPVA
NFHLQNGAVLWRINWMADVSLRGITGSCGLMANYRYFLEETGPNSTSYLGSKIIKASEQV
LSLVAQFQKNSKL
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BDBM50190401 |
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n/a |
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Name | BDBM50190401 |
Synonyms: | CHEMBL211177 | tert-butyl-(3S)-3-{[(5R)-5-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-4,5-dihydro-isoxazole-3-carbonyl]-amino}-butanoate |
Type | Small organic molecule |
Emp. Form. | C15H20F6N2O5 |
Mol. Mass. | 422.3201 |
SMILES | C[C@@H](CC(=O)OC(C)(C)C)NC(=O)C1=NO[C@H](C1)C(O)(C(F)(F)F)C(F)(F)F |t:13| |
Structure |
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