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TargetDeoxyuridine 5'-triphosphate nucleotidohydrolase
LigandBDBM50190549
Substrate/Competitorn/a
Meas. Tech.ChEMBL_373621 (CHEMBL869761)
Ki 240±n/a nM
Citation Nguyen, CRuda, GFSchipani, AKasinathan, GLeal, IMusso-Buendia, AKaiser, MBrun, RRuiz-Pérez, LMSahlberg, BLJohansson, NGGonzalez-Pacanowska, DGilbert, IH Acyclic nucleoside analogues as inhibitors of Plasmodium falciparum dUTPase. J Med Chem49:4183-95 (2006) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Deoxyuridine 5'-triphosphate nucleotidohydrolase
Name:Deoxyuridine 5'-triphosphate nucleotidohydrolase
Synonyms:dUTP pyrophosphatase
Type:Protein
Mol. Mass.:19574.43
Organism:Plasmodium falciparum
Description:Q8II92
Residue:173
Sequence:
MHLKIVCLSDEVREMYKNHKTHHEGDSGLDLFIVKDEVLKPKSTTFVKLGIKAIALQYKS
NYYYKCEKSENKKKDDDKSNIVNTSFLLFPRSSISKTPLRLANSIGLIDAGYRGEIIAAL
DNTSDQEYHIKKNDKLVQLVSFTGEPLSFELVEELDETSRGEGGFGSTSNNKY
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BDBM50190549
n/a
NameBDBM50190549
Synonyms:1-[4-hydroxy-3-(tritylaminomethyl)butyl]uracil | CHEMBL378101
TypeSmall organic molecule
Emp. Form.C28H29N3O3
Mol. Mass.455.5482
SMILESOCC(CCn1ccc(=O)[nH]c1=O)CNC(c1ccccc1)(c1ccccc1)c1ccccc1
Structure
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