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TargetDeoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial
LigandBDBM50190565
Substrate/Competitorn/a
Meas. Tech.ChEMBL_373622 (CHEMBL869762)
Ki 260000±n/a nM
Citation Nguyen, CRuda, GFSchipani, AKasinathan, GLeal, IMusso-Buendia, AKaiser, MBrun, RRuiz-Pérez, LMSahlberg, BLJohansson, NGGonzalez-Pacanowska, DGilbert, IH Acyclic nucleoside analogues as inhibitors of Plasmodium falciparum dUTPase. J Med Chem49:4183-95 (2006) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial
Name:Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial
Synonyms:DUT | DUT_HUMAN | Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) | Deoxyuridine triphosphatase (dUTPase) | dUTP pyrophosphatase
Type:Enzyme
Mol. Mass.:26574.03
Organism:Homo sapiens (Human)
Description:P33316
Residue:252
Sequence:
MTPLCPRPALCYHFLTSLLRSAMQNARGARQRAEAAVLSGPGPPLGRAAQHGIPRPLSSA
GRLSQGCRGASTVGAAGWKGELPKAGGSPAPGPETPAISPSKRARPAEVGGMQLRFARLS
EHATAPTRGSARAAGYDLYSAYDYTIPPMEKAVVKTDIQIALPSGCYGRVAPRSGLAAKH
FIDVGAGVIDEDYRGNVGVVLFNFGKEKFEVKKGDRIAQLICERIFYPEIEEVQALDDTE
RGSGGFGSTGKN
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BDBM50190565
n/a
NameBDBM50190565
Synonyms:1-[2-(hydroxymethyl)-4-(trityloxy)butyl]uracil | CHEMBL385167
TypeSmall organic molecule
Emp. Form.C28H28N2O4
Mol. Mass.456.5329
SMILESOCC(CCOC(c1ccccc1)(c1ccccc1)c1ccccc1)Cn1ccc(=O)[nH]c1=O
Structure
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