Reaction Details |
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Target | Deoxyuridine 5'-triphosphate nucleotidohydrolase |
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Ligand | BDBM50190564 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_373621 (CHEMBL869761) |
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Ki | 1300±n/a nM |
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Citation | Nguyen, C; Ruda, GF; Schipani, A; Kasinathan, G; Leal, I; Musso-Buendia, A; Kaiser, M; Brun, R; Ruiz-Pérez, LM; Sahlberg, BL; Johansson, NG; Gonzalez-Pacanowska, D; Gilbert, IH Acyclic nucleoside analogues as inhibitors of Plasmodium falciparum dUTPase. J Med Chem49:4183-95 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Deoxyuridine 5'-triphosphate nucleotidohydrolase |
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Name: | Deoxyuridine 5'-triphosphate nucleotidohydrolase |
Synonyms: | dUTP pyrophosphatase |
Type: | Protein |
Mol. Mass.: | 19574.43 |
Organism: | Plasmodium falciparum |
Description: | Q8II92 |
Residue: | 173 |
Sequence: | MHLKIVCLSDEVREMYKNHKTHHEGDSGLDLFIVKDEVLKPKSTTFVKLGIKAIALQYKS
NYYYKCEKSENKKKDDDKSNIVNTSFLLFPRSSISKTPLRLANSIGLIDAGYRGEIIAAL
DNTSDQEYHIKKNDKLVQLVSFTGEPLSFELVEELDETSRGEGGFGSTSNNKY
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BDBM50190564 |
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n/a |
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Name | BDBM50190564 |
Synonyms: | 1-[4-acetyloxy-3-(tritylaminomethyl)butyl]uracil | CHEMBL208621 |
Type | Small organic molecule |
Emp. Form. | C30H31N3O4 |
Mol. Mass. | 497.5848 |
SMILES | CC(=O)OCC(CCn1ccc(=O)[nH]c1=O)CNC(c1ccccc1)(c1ccccc1)c1ccccc1 |
Structure |
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