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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Neprilysin | ||
| Ligand | BDBM50190772 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_369150 (CHEMBL862877) | ||
| IC50 | 370±n/a nM | ||
| Citation |  Pryde, DC; Maw, GN; Planken, S; Platts, MY; Sanderson, V; Corless, M; Stobie, A; Barber, CG; Russell, R; Foster, L; Barker, L; Wayman, C; Van Der Graaf, P; Stacey, P; Morren, D; Kohl, C; Beaumont, K; Coggon, S; Tute, M Novel selective inhibitors of neutral endopeptidase for the treatment of female sexual arousal disorder. Synthesis and activity of functionalized glutaramides. J Med Chem49:4409-24 (2006) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Neprilysin | |||
| Name: | Neprilysin | ||
| Synonyms: | Atriopeptidase | CALLA | CD_antigen=CD10 | Common acute lymphocytic leukemia antigen | EPN | Enkephalinase | MME | NEP | NEP_HUMAN | Neutral Endopeptidase (NEP) | Neutral endopeptidase | Neutral endopeptidase 24.11 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 85505.38 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P08473 | ||
| Residue: | 750 | ||
| Sequence: |
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| BDBM50190772 | |||
| n/a | |||
| Name | BDBM50190772 | ||
| Synonyms: | CHEMBL213240 | cis-2-((1-((4-(dimethylcarbamoyl)cyclohexyl)carbamoyl)cyclopentyl)methyl)pentanoic acid | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H36N2O4 | ||
| Mol. Mass. | 380.5215 | ||
| SMILES | CCCC(CC1(CCCC1)C(=O)N[C@H]1CC[C@H](CC1)C(=O)N(C)C)C(O)=O |wU:13.13,16.20,(-6.79,-6.07,;-6.79,-7.61,;-5.46,-8.38,;-5.46,-9.92,;-4.12,-10.69,;-2.79,-9.92,;-4.04,-9.02,;-3.56,-7.55,;-2.02,-7.55,;-1.54,-9.02,;-1.46,-10.69,;-1.46,-12.23,;-.12,-9.92,;1.21,-10.69,;2.53,-9.92,;3.87,-10.7,;3.87,-12.24,;2.53,-13,;1.2,-12.23,;5.2,-13.02,;5.19,-14.56,;6.53,-12.25,;7.86,-13.03,;6.54,-10.71,;-6.79,-10.69,;-8.12,-9.92,;-6.79,-12.23,)| | ||
| Structure | 
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