Reaction Details |
| Report a problem with these data |
Target | Proteinase-activated receptor 1 |
---|
Ligand | BDBM50173419 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_401364 (CHEMBL854222) |
---|
IC50 | 11±n/a nM |
---|
Citation | Xia, Y; Chackalamannil, S; Chan, TM; Czarniecki, M; Doller, D; Eagen, K; Greenlee, WJ; Tsai, H; Wang, Y; Ahn, HS; Boykow, GC; McPhail, AT Himbacine derived thrombin receptor (PAR-1) antagonists: structure-activity relationship of the lactone ring. Bioorg Med Chem Lett16:4969-72 (2006) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Proteinase-activated receptor 1 |
---|
Name: | Proteinase-activated receptor 1 |
Synonyms: | CF2R | Coagulation factor II receptor | F2R | PAR-1 | PAR1 | PAR1_HUMAN | Proteinase activated receptor 1 | Proteinase-activated receptor 1 (PAR-1) | TR | Thrombin receptor | Thrombin receptor/ Proteinase-activated receptor 1(Par-1) |
Type: | Protein |
Mol. Mass.: | 47450.07 |
Organism: | Homo sapiens (Human) |
Description: | P25116 |
Residue: | 425 |
Sequence: | MGPRRLLLVAACFSLCGPLLSARTRARRPESKATNATLDPRSFLLRNPNDKYEPFWEDEE
KNESGLTEYRLVSINKSSPLQKQLPAFISEDASGYLTSSWLTLFVPSVYTGVFVVSLPLN
IMAIVVFILKMKVKKPAVVYMLHLATADVLFVSVLPFKISYYFSGSDWQFGSELCRFVTA
AFYCNMYASILLMTVISIDRFLAVVYPMQSLSWRTLGRASFTCLAIWALAIAGVVPLLLK
EQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAVFFFVPLIISTVCYVSIIRCLSSS
AVANRSKKSRALFLSAAVFCIFIICFGPTNVLLIAHYSFLSHTSTTEAAYFAYLLCVCVS
SISCCIDPLIYYYASSECQRYVYSILCCKESSDPSSYNSSGQLMASKMDTCSSNLNNSIY
KKLLT
|
|
|
BDBM50173419 |
---|
n/a |
---|
Name | BDBM50173419 |
Synonyms: | (3R,3aS,4S,4aR,8aS,9aR)-3-Methyl-4-{(E)-2-[5-(3-trifluoromethyl-phenyl)-pyridin-2-yl]-vinyl}-decahydro-naphtho[2,3-c]furan-1-one | (3R,3aS,4S,4aR,8aS,9aR)-3-methyl-4-(2-(5-(3-(trifluoromethyl)phenyl)pyridin-2-yl)vinyl)-decahydronaphtho[2,3-c]furan-1(3H)-one | (3R,3aS,4S,4aR,8aS,9aR,E)-3-methyl-4-(2-(5-(3-(trifluoromethyl)phenyl)pyridin-2-yl)vinyl)-decahydronaphtho[2,3-c]furan-1(3H)-one | CHEMBL371069 | SCH-205831 |
Type | Small organic molecule |
Emp. Form. | C27H28F3NO2 |
Mol. Mass. | 455.5119 |
SMILES | C[C@H]1OC(=O)[C@@H]2C[C@@H]3CCCC[C@H]3[C@H](\C=C\c3ccc(cn3)-c3cccc(c3)C(F)(F)F)[C@H]12 |
Structure |
|