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TargetMetallo-beta-lactamase type 2
LigandBDBM50191387
Substrate/Competitorn/a
Meas. Tech.ChEMBL_365444 (CHEMBL869111)
IC50 120±n/a nM
Citation Venkatesan, AMAgarwal, AAbe, TUshirogochi, HYamamura, IAdo, MTsuyoshi, TDos Santos, OGu, YSum, FWLi, ZFrancisco, GLin, YIPetersen, PJYang, YKumagai, TWeiss, WJShlaes, DMKnox, JRMansour, TS Structure-activity relationship of 6-methylidene penems bearing 6,5 bicyclic heterocycles as broad-spectrum beta-lactamase inhibitors: evidence for 1,4-thiazepine intermediates with C7 R stereochemistry by computational methods. J Med Chem49:4623-37 (2006) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Metallo-beta-lactamase type 2
Name:Metallo-beta-lactamase type 2
Synonyms:BLAB_BACFG | Beta-lactamase type II | ccrA | cfiA
Type:PROTEIN
Mol. Mass.:27252.87
Organism:Bacteroides fragilis
Description:ChEMBL_1502123
Residue:249
Sequence:
MKTVFILISMLFPVAVMAQKSVKISDDISITQLSDKVYTYVSLAEIEGWGMVPSNGMIVI
NNHQAALLDTPINDAQTEMLVNWVTDSLHAKVTTFIPNHWHGDCIGGLGYLQRKGVQSYA
NQMTIDLAKEKGLPVPEHGFTDSLTVSLDGMPLQCYYLGGGHATDNIVVWLPTENILFGG
CMLKDNQATSIGNISDADVTAWPKTLDKVKAKFPSARYVVPGHGDYGGTELIEHTKQIVN
QYIESTSKP
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  Blast E-value cutoff:
BDBM50191387
n/a
NameBDBM50191387
Synonyms:(5R),(6Z)-6-(7-methyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-2-ylmethylene)-7-oxo-4-thia-1-aza-bicyclo-[3.2.0]hept-2-ene-2-carboxylic acid sodium salt | CHEMBL212478
TypeSmall organic molecule
Emp. Form.C14H13N4O3S
Mol. Mass.317.344
SMILESCN1CCn2cc(\C=C3/[C@H]4SC=C(N4C3=O)C([O-])=O)nc2C1 |c:11|
Structure
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