Reaction Details |
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Target | RNA-directed RNA polymerase |
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Ligand | BDBM50191530 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_376990 (CHEMBL866684) |
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IC50 | 58±n/a nM |
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Citation | Hirashima, S; Suzuki, T; Ishida, T; Noji, S; Yata, S; Ando, I; Komatsu, M; Ikeda, S; Hashimoto, H Benzimidazole derivatives bearing substituted biphenyls as hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitors: structure-activity relationship studies and identification of a potent and highly selective inhibitor JTK-109. J Med Chem49:4721-36 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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RNA-directed RNA polymerase |
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Name: | RNA-directed RNA polymerase |
Synonyms: | Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein |
Type: | Protein |
Mol. Mass.: | 25173.95 |
Organism: | Hepatitis C virus |
Description: | Q8JXU8 |
Residue: | 229 |
Sequence: | RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLT
CYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPP
QPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIM
FAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
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BDBM50191530 |
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n/a |
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Name | BDBM50191530 |
Synonyms: | 2-[4-(4'-carboxy-4-chlorobiphenyl-2-ylmethoxy)phenyl]-1-cyclohexyl-1H-benzimidazole-5-carboxylic acid | CHEMBL373930 |
Type | Small organic molecule |
Emp. Form. | C34H29ClN2O5 |
Mol. Mass. | 581.057 |
SMILES | OC(=O)c1ccc(cc1)-c1ccc(Cl)cc1COc1ccc(cc1)-c1nc2cc(ccc2n1C1CCCCC1)C(O)=O |
Structure |
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