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TargetRNA-directed RNA polymerase
LigandBDBM50191504
Substrate/Competitorn/a
Meas. Tech.ChEMBL_376990 (CHEMBL866684)
IC50 480±n/a nM
Citation Hirashima, SSuzuki, TIshida, TNoji, SYata, SAndo, IKomatsu, MIkeda, SHashimoto, H Benzimidazole derivatives bearing substituted biphenyls as hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitors: structure-activity relationship studies and identification of a potent and highly selective inhibitor JTK-109. J Med Chem49:4721-36 (2006) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
RNA-directed RNA polymerase
Name:RNA-directed RNA polymerase
Synonyms:Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein
Type:Protein
Mol. Mass.:25173.95
Organism:Hepatitis C virus
Description:Q8JXU8
Residue:229
Sequence:
RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLT
CYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPP
QPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIM
FAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
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  Blast E-value cutoff:
BDBM50191504
n/a
NameBDBM50191504
Synonyms:1-cyclohexyl-2-[4-(4,3'-dichlorobiphenyl-2-ylmethoxy)phenyl]-1H-benzimidazole-5-carboxylic acid | CHEMBL378284
TypeSmall organic molecule
Emp. Form.C33H28Cl2N2O3
Mol. Mass.571.493
SMILESOC(=O)c1ccc2n(C3CCCCC3)c(nc2c1)-c1ccc(OCc2cc(Cl)ccc2-c2cccc(Cl)c2)cc1
Structure
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