Reaction Details |
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Target | RNA-directed RNA polymerase |
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Ligand | BDBM50191519 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_376990 (CHEMBL866684) |
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IC50 | 16±n/a nM |
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Citation | Hirashima, S; Suzuki, T; Ishida, T; Noji, S; Yata, S; Ando, I; Komatsu, M; Ikeda, S; Hashimoto, H Benzimidazole derivatives bearing substituted biphenyls as hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitors: structure-activity relationship studies and identification of a potent and highly selective inhibitor JTK-109. J Med Chem49:4721-36 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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RNA-directed RNA polymerase |
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Name: | RNA-directed RNA polymerase |
Synonyms: | Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein |
Type: | Protein |
Mol. Mass.: | 25173.95 |
Organism: | Hepatitis C virus |
Description: | Q8JXU8 |
Residue: | 229 |
Sequence: | RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLT
CYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPP
QPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIM
FAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
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BDBM50191519 |
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n/a |
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Name | BDBM50191519 |
Synonyms: | 2-{4-[4-(acetylmethylamino)-4'-chlorobiphenyl-2-ylmethoxy]-2-fluorophenyl}-1-cyclohexyl-1H-benzimidazole-5-carboxylic acid | CHEMBL374567 |
Type | Small organic molecule |
Emp. Form. | C36H33ClFN3O4 |
Mol. Mass. | 626.116 |
SMILES | CN(C(C)=O)c1ccc(c(COc2ccc(-c3nc4cc(ccc4n3C3CCCCC3)C(O)=O)c(F)c2)c1)-c1ccc(Cl)cc1 |
Structure |
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