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TargetRNA-directed RNA polymerase
LigandBDBM50191519
Substrate/Competitorn/a
Meas. Tech.ChEMBL_376990 (CHEMBL866684)
IC50 16±n/a nM
Citation Hirashima, SSuzuki, TIshida, TNoji, SYata, SAndo, IKomatsu, MIkeda, SHashimoto, H Benzimidazole derivatives bearing substituted biphenyls as hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitors: structure-activity relationship studies and identification of a potent and highly selective inhibitor JTK-109. J Med Chem49:4721-36 (2006) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
RNA-directed RNA polymerase
Name:RNA-directed RNA polymerase
Synonyms:Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein
Type:Protein
Mol. Mass.:25173.95
Organism:Hepatitis C virus
Description:Q8JXU8
Residue:229
Sequence:
RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLT
CYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPP
QPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIM
FAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
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  Blast E-value cutoff:
BDBM50191519
n/a
NameBDBM50191519
Synonyms:2-{4-[4-(acetylmethylamino)-4'-chlorobiphenyl-2-ylmethoxy]-2-fluorophenyl}-1-cyclohexyl-1H-benzimidazole-5-carboxylic acid | CHEMBL374567
TypeSmall organic molecule
Emp. Form.C36H33ClFN3O4
Mol. Mass.626.116
SMILESCN(C(C)=O)c1ccc(c(COc2ccc(-c3nc4cc(ccc4n3C3CCCCC3)C(O)=O)c(F)c2)c1)-c1ccc(Cl)cc1
Structure
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